「微生物生理学」(Microbial Physiology)は、微生物の営みを生理学的な角度から研究する学問領域です。具体的にいえば、生育、環境ストレス応答、発酵と代謝などです。換言すれば、微生物の「生きざま」を明らかにするともいえるでしょう。究極的にはその成果をもとに、微生物の有効活用を目指します。研究対象としている微生物は、私たちの食生活やバイオマスの利用に直結している「モノつくり」に関わる微生物と、健康に直結する「おなかの中の微生物」で、それぞれオリジナリティーの高い研究テーマが設定されています。”微生物の生理”は「微生物のゲノムが与えられた環境において発現している総体」ですから、その解明は膨大で大変骨の折れる仕事です。少し前までは手探りの状態で研究を進めなければならないこともしばしばでした。しかし今日、多くの微生物のゲノムが解読され、事態は一変しつつあります。私たちは従来的な遺伝生化学的手法に加えて、ゲノム情報に基づいて微生物を丸ごと解析する機能ゲノム学的手法を手中にしつつあるからです。すなわち、トランスクリプトーム解析、プロテオーム解析等がそれです。これらの手法を取入れることで、解析情報量と精度は飛躍的に上昇します。現在私たちの研究室では、従来的な研究手法とこれらの新しい手法を融合させることで、それぞれの研究対象で多くの興味深いデータが得られつつあります。
私たちは平成18年度から研究室名を新たに「微生物生理学」といたしました。この名称は、言葉としては伝統的でむしろ古典的な響きがありますが、私たちは今まさに時を得て、新しい時代を切り開ける新領域であると考えています。
このようなチャレンジングな学問領域に飛び込んで、微生物の有効活用を目指して力を合わせてくれる学生諸君を大歓迎します。「微生物生理学」研究室へ来れ！！
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| 氏名 | 横田 篤(よこた あつし) |
| 出身校 | 北海道大学農学部農芸化学科卒業 |
| 卒業後の略歴 |
1984年 北海道大学農学部農芸化学科博士課程修了(農学博士)
1984年
味の素株式会社中央研究所勤務
1989年
北海道大学農学部助手
1993年
北海道大学農学部助教授
1996年 - 1997年
オランダ国フローニンゲン大学へ留学
2000年
北海道大学大学院農学研究科教授
2006年
組織変更により 北海道大学大学院農学研究院教授
現在に至る。
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| 専門 | 微生物生理学、胃腸内圏微生物学 |
| 学会役員等 | 日本生物工学会北日本支部支部長、日本乳酸菌学会理事、FEMS Microbiology Letters 編集委員 |
| 受賞歴 | 1995年 日本農芸化学会より農芸化学奨励賞を受賞 |
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| ■より詳しい情報はこちらから検索できます |
■学術論文（現在の研究に関連する主要な論文のみを示しました）
1. S. Takao, A. Yokota and M. Tanida. L-Malic acid fermentation by a mixed culture of Rhizopus arrhizus and Paecilomyces varioti.
Journal of Fermentation Technology, 61, 643-645 (1983).
2. S. Takao, A. Yokota and M. Tanida. Enzymatic production of tryptophan coupled to pyruvic acid fermentation.
Journal of Fermentation Technology, 62, 329-334 (1984).
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3. A. Yokota and S. Takao. Conversion of pyruvic acid fermentation to tryptophan production by the combination of pyruvic acid-producing microorganisms and Enterobacter aerogenes having high tryptophanase activity.
Agricultural and Biological Chemistry, 48, 2663-2668 (1984).
4. I. Shiio, A. Yokota and S. Sugimoto. Effect of pyruvate kinase deficiency on L-lysine productivities of mutants with feedback-resistant aspartokinases.
Agricultural and Biological Chemistry, 51, 2485-2493 (1987).
5. A. Yokota and I. Shiio. Effects of reduced citrate synthase activity andfeedback-resistant phosphoenolpyruvate carboxylase on lysine productivities of Brevibacterium flavum mutants.
Agricultural and Biological Chemistry, 52, 455-463 (1988).
6. I. Shiio, A. Yokota, Y. Toride and S. Sugimoto. Threonine production by dihydrodipicolinate synthase-defective mutants of Brevibacterium flavum.
Agricultural and Biological Chemistry, 53, 41-48 (1989).
7. A. Yokota and S. Takao. Pyruvic acid production by lipoic acid auxotrophs of Enterobacter aerogenes.
Agricultural and Biological Chemistry, 53, 705-711 (1989).
8. A. Yokota, S. Oita and S. Takao. Tryptophan production by a lipoic acidauxotroph of Enterobacter aerogenes having both pyruvic acid productivity and high tryptophanase activity.
Agricultural and Biological Chemistry, 53, 2037-2044 (1989).
9. I. Shiio, A. Yokota and K. Kawamura. Isolation and properties of dihydrodipicolinate synthase-defective threonine-producing mutants from a Brevibacterium flavum strain with feedback-sensitive aspartokinase.
Agricultural and Biological Chemistry, 53, 2169-2175 (1989).
10. A. Yokota and I. Shiio. Dihydrodipicolinate synthase deficiency of Brevibacterium flavum strain BB69, a threonine-producing mutant with a feedback-resistant homoserine dehydrogenase.
Agricultural and Biological Chemistry, 54, 547-548 (1990).
11. S. Oita, A. Yokota and S. Takao. Enzymatic production of tryptophan using a lipoic acid and thiamine double auxotroph of Enterobacter aerogenes having both pyruvic acid productivity and high tryptophanase activity.
Journal of Fermentation and Bioengineering, 69, 256-258 (1990).
12. J. Hariantono, A. Yokota, S. Takao and F. Tomita. Ethanol production from raw starch by simultaneous fermentation using Schizosaccharomyces pombe and a raw starch saccharifying enzyme from Corticium rolfsii.
Journal of Fermentation and Bioengineering, 71, 367-369 (1991).
13. A. Yokota, S. Hirayama, K. Enomoto, Y. Miura, S. Takao and F. Tomita: Production of inulin fructotransferase (depolymerizing) by Arthrobacter sp. H65-7 and preparation of DFA III from inulin by the enzyme.
Journal of Fermentation and Bioengineering, 72, 258-261 (1991).
14. A. Yokota, K. Enomoto and F. Tomita. Purification and properties of an inulin fructotransferase (depolymerizing) from Arthrobacter sp. H65-7.
Journal of Fermentation and Bioengineering, 72, 262-265 (1991).
15. A. Yokota, K. Kondo, M. Nakagawa, I. Kojima and F. Tomita. Production of levanbiose by levan-degrading enzyme from Streptomyces exfoliatus F3-2.
Bioscience Biotechnology and Biochemistry, 57, 745-749 (1993).
16. K. Kawasaki, A. Yokota, S. Oita, C. Kobayashi, S. Yoshikawa, S. Kawamoto, S. Takao and F. Tomita. Cloning and characterization of a tryptophanase gene from Enterobacter aerogenes SM-18.
Journal of General Microbiology, 139, 3275-3281 (1993). >>PubMed
17. A. Yokota, H. Shimizu, Y. Terasawa, N. Takaoka and F. Tomita. Pyruvic acid production by a lipoic acid auxotroph of Escherichia coli W1485.
Applied Microbiology and Biotechnology, 41, 638-643 (1994).
18. A. Yokota, Y. Terasawa, N. Takaoka, H. Shimizu and F. Tomita. Pyruvic acid production by an F1-ATPase-defective mutant of Escherichia coli W1485lip2.
Bioscience Biotechnology and Biochemistry, 58, 2164-2167 (1994).
19. K. Kawasaki, A. Yokota and F. Tomita. Enzymatic synthesis of L-tryptophan by Enterobacter aerogenes tryptophanase highly expressed in Escherichia coli, and some properties of the purified enzyme.
Bioscience Biotechnology and Biochemistry, 59, 1938-1943 (1995).
20. A. Yokota, S. Amachi, S. Ishii and F. Tomita. Acid sensitivity of a mutant of Lactococcus lactis subsp. lactis C2 with reduced membrane-bound ATPase activity.
Bioscience Biotechnology and Biochemistry, 59, 2004-2007 (1995).
21. A. Yokota, O. Yamauchi and F. Tomita. Production of inulotriose from inulin by inulin-degrading enzyme from Streptomyces rochei E87.
Letters in Applied Microbiology, 21, 330-333 (1995).
22. Y. Nagasaka, N. Muraki, A. Kimura, M. Suto, A. Yokota and F. Tomita. Cloning of Corticium rolfsii glucoamylase cDNA and its expression in Saccharomyces cerevisiae.
Applied Microbiology and Biotechnology, 44, 451-458 (1995). >>PubMed
23. K. Kawasaki, A. Yokota, F. Tomita. L-Tryptophan production by a pyruvic acid-producing Escherichia coli strain carrying the Enterobacter aerogenes tryptophanase gene.
Journal of Fermentation and Bioengineering, 82, 604-606 (1996).
24. H. Sakurai, A. Yokota and F. Tomita. Molecular cloning of an inulin fructotransferase (Depolymerizing) gene from Arthrobacter sp. H65-7 and its expression in Escherichia coli.
Bioscience Biotechnology and Biochemistry, 61, 87-92 (1997).
25. A. Yokota, M. Henmi, N. Takaoka, C. Hayashi, Y. Takezawa, Y. Fukumori and F. Tomita. Enhancement of glucose metabolism in a pyruvic acid-hyperproducing Escherichia coli mutant defective in F1-ATPase activity.
Journal of Fermentation and Bioengineering, 83, 132-138 (1997).
26. H. Sakurai, A. Yokota Y. Sumita, Y. Mori, H. Matsui and F. Tomita. Metabolism of DFA III by Arthrobacter sp. H65-7: Purification and properties of a DFAIII hydrolysis enzyme (DFAIIIase).
Bioscience Biotechnology and Biochemistry, 61, 989-993 (1997).
27. K. Saito, H. Goto, A. Yokota and F. Tomita. Purification of levan fructotransferase from Arthrobacter nicotinovorans GS-9 and production of DFA IV from levan by the enzyme.
Bioscience Biotechnology and Biochemistry, 61, 1705-1709 (1997).
28. K. Saito, A. Yokota and F. Tomita. Molecular cloning of levan fructotransferase gene from Arthrobacter nicotinovorans GS-9 and its expression in Escherichia coli.
Bioscience Biotechnology and Biochemistry, 61, 2076-2079 (1997).
29. S. Amachi, K. Ishikawa, S. Toyoda, Y. Kagawa, A. Yokota and F.Tomita. Characterization of a mutant of Lactococcus lactis with reduced membrane-bound ATPase activity under acidic conditions.
Bioscience Biotechnology and Biochemistry, 62, 1574-1580 (1998).
30. Y. Nagasaka, K. Kurosawa, A. Yokota and F. Tomita. Purification and properties of the raw-starch-digesting glucoamylases from Corticium rolfsii.
Applied Microbiology and Biotechnology, 50, 323-330 (1998). >>PubMed
31. K. Saito, T. Hira, T. Suzuki, H. Hara, A. Yokota and F. Tomita. Effects of DFA IV in rats: Calcium absorption and metabolism of DFA IV by intestinal microorganisms.
Bioscience Biotechnology and Biochemistry, 63, 655-661 (1999).
32. K. Saito, K. Kondo, I. Kojima, A. Yokota and F. Tomita. Purification and characterization of 2,6-β-D-fructan 6-levanbiohydrolase from Streptomyces exfoliatus F3-2.
Applied and Environmental Microbiology, 66, 252-256 (2000). >>PubMed
33. A. Yokota, M. Veenstra, P. Kurdi, H. W. van Veen and W. N. Konings. Cholate resistance in Lactococcus lactis is mediated by an ATP-dependent multispecific organic anion transporter.
Journal of Bacteriology, 182, 5196-5201 (2000). >>PubMed
34. P. Kurdi, H. W. van Veen, H. Tanaka, I. Mierau, W. N. Konings, G. W. Tannock, F. Tomita and A. Yokota. Cholic acid is accumulated spontaneously, driven by membrane ΔpH, in many lactobacilli.
Journal of Bacteriology, 182, 6525-6528 (2000). >>PubMed
35. H. Sekine, T. Shimada, C. Hayashi, A. Ishiguro, F. Tomita and A. Yokota. H+-ATPase defect in Corynebacterium glutamicum abolishes glutamic acid production with enhancement of glucose consumption rate.
Applied Microbiology and Biotechnology, 57, 534-540 (2001). >>PubMed
36. Niamsup, P., Sujaya, I. N., Tanaka, M., Sone, T., Hanada, S., Kamagata, Y., Lumyong, S., Assavanig, A., Asano, K., Tomita, F., and Yokota, A.: Lactobacillus thermotolerans sp. nov., a novel thermotolerant species isolated from chiken faeces.
International Journal of Systematic and Evolutionary Microbiology, 53, 263-268 (2003). >>PubMed
37. K. Saito, Y. Oda, F. Tomita and A. Yokota. Molecular cloning of the gene for 2,6-beta-D-fructan 6-levanbiohydrolase from Streptomyces exfoliates F3-2.
FEMS Microbiology Letters, 218, 265-270 (2003). >>PubMed
38. K. Saito, Y. Sumita, Y. Nagasaka, F. Tomita and A. Yokota. Molecular cloning of the gene encoding the di-D-fructofuranose 1,2’:2,3’ dianhydride hydrolysis enzyme (DFA IIIase) from Arthrobacter sp. H65-7.
Journal of Bioscience and Bioengineering, 95, 538-540 (2003). >>PubMed
39. P. Kurdi, H. Tanaka, H. W. van Veen, K. Asano, F. Tomita and A. Yokota.: Cholic acid accumulation and its diminution by short-chain fatty acids in bifidobacteria.
Microbiology, 149, 2031-2037 (2003). >>PubMed
40. Y. Sawatari, H. Sugiyama, Y. Suzuki, A. Hanaoka, K. Saito,H. Yamauchi, S. Okada and A. Yokota. Development of the fermented instant Chinese noodle using Lactobacillus plantarum.
Food Microbiology, 22, 539-546 (2005).
41. ASM. Selim, P. Boonkumklao, T. Sone, A. Assavanig, M. Wada and A. Yokota. Development and assessment of a Real-Time PCR assay for the rapid and sensitive detection of a novel thermotolerant bacterium, Lactobacillus thermotolerans, in chicken feces.
Applied and Environmental Microbiology, 71, 4214-4219 (2005). >>PubMed
42. R. Aoki, M. Wada, N. Takesue, K. Tanaka and A. Yokota. Enhanced glutamic acid production by a H+-ATPase-defective mutant of Corynebacterium glutamicum.
Bioscience Biotechnology and Biochemistry, 69, 1466-1472 (2005).
43. A. Dinoto, A. Suksomcheep, S. Ishizuka, H. Kimura, S. Hanada, Y. Kamagata, K. Asano, F. Tomita, and A. Yokota. Modulation of Rat Cecal Microbiota by the Administration of Raffinose and Encapsulated Bifidobacterium breve.
Applied and Environmental Microbiology, 72, 784-792 (2006). >>PubMed
44. P. Kurdi, K. Kawanishi, K. Mizutani, and A. Yokota. Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria.
Journal of Bacteriology, 188, 1979-1986 (2006). >>PubMed
45. Sakiko Noda, Yuji Takezawa, Tomohiko Mizutani, Tomoaki Asakura, Eiichiro Nishiumi, Kazunori Onoe, Masaru Wada, Fusao Tomita, Kazunobu Matsushita and Atsushi Yokota. Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F1-ATPase.
Journal of Bacteriology, 188, 6869-6876 (2006). >>PubMed
46. A. Dinoto, T. M. Marques, K. Sakamoto, S. Fukiya, J. Watanabe, S. Ito and A. Yokota. Population dynamics of Bifidobacterium species in human feces during raffinose administration monitored by FISH-flow cytometry.
Appl. Environ. Microbiol. 72, 7739-7747 (2006). >>PubMed
47. Y. Sawatari, T. Hirano, and A. Yokota. Development of food grade media for the preparation of Lactobacillus plantarum starter culture.
Journal of General and Applied Microbiology. 52, 349-356 (2006). >>PubMed
48. M. Wada, K. Narita, A. Yokota, Alanine production in an H+-ATPase- and lactate dehydrogenase-defective mutant of Escherichia coli expressing alanine dehydrogenase.
Appl. Microbiol. Biotechnol., 76: 819-825 (2007). >>PubMed
49. L. Li, M. Wada, A. Yokota, A comparative proteomic approach to understand the adaptations of an H+-ATPase-defective mutant of Corynebacterium glutamicum ATCC14067 to energy deficiencies.
Proteomics, 7: 3348-3357 (2007). >>PubMed
50. L. Li, M. Wada, and A. Yokota, Cytoplasmic proteome reference map for a glutamic acid-producing Corynebacterium glutamicum ATCC14067.
Proteomics, 7: 4317-4322 (2007). >>PubMed
51. M. P. Ongol, Y. Sawatari, Y. Ebina, T. Sone, M. Tanaka, F. Tomita, A. Yokota and K. Asano. Yoghurt fermented by Lactobacillus delbrueckii subsp. bulgaricus H+-ATPase-defective mutants exhibits enhanced viability of Bifidobacterium breve during storage.
International Journal of Food Microbiology, 116: 358-366 (2007). >>PubMed
52. Y. Sawatari and A.Yokota. Diversity and mechanisms of alkali tolerance in lactobacilli.
Applied and Environmental Microbiology, 73: 3909-3915 (2007). >>PubMed
53. M. Wada, K. Okabe, M. Kataoka, S. Shimizu, A. Yokota, H. Takagi, Distribution of L-azetidine-2-carboxylate N-acetyltransferese in yeast.
Bioscience Biotechnology and Biochemistry, 72: 582-586, (2008). >>PubMed
54. E. Yahata, Y. Sawatari, H. Sugiyama, A. Hanakoka, A. Yokota and H. Saruyama. Change of proteins in instant Chinese noodle by the fermentation of Lactobacillus plantarum NRIC0380 affects the noodle quality.
Food Science and Technology Research. 14: 285-292 (2008). >>Journal site
55. S. Ishizuka, A Iwama, A. Dinoto, A. Suksomcheep, K. Maeta, T. Kasai, H. Hara and A. Yokota. Synbiotic promotion of epithelial proliferation by orally ingested encapsulated Bifidobacterium breve and raffinose in the small intestine of rats.
Molecular Nutrition & Food Research. 2008 Oct 7. >>PubMed
56. M. Wada, N. Hijikata, R. Aoki, N. Takesue, A. Yokota. Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase.
Bioscience Biotechnology and Biochemistry, 72: 2959-2965 (2008). >>PubMed
57. Hiroto Kikuchi, Masanao Inoue, Hidetoshi Saito, Hiroaki Sakurai, Tsutomu Aritsuka, Fusao Tomita, and Atsushi Yokota. Industrial production of difructose anhydride III (DFA III) from crude inulin extracted from chicory roots using Arthrobacter sp. H65-7 fructosyltransferase.
Journal of Bioscience and Bioengineering, 107: 262-265 (2009). >>PubMed
58. Senoura T, Taguchi H, Ito S, Hamada S, Matsui H, Fukiya S, Yokota A, Watanabe J, Wasaki J, Ito S. Identification of the Cellobiose 2-Epimerase Gene in the Genome of Bacteroides fragilis NCTC 9343.
Bioscience Biotechnology and Biochemistry, 73: 400-406 (2009). >>PubMed
59. Satoru Fukiya, Miki Arata, Hiroko Kawashima, Daisuke Yoshida, Maki Kaneko, Kimiko Minamida, Jun Watanabe, Yoshio Ogura, Kiyohisa Uchida, Kikuji Itoh, Masaru Wada, Susumu Ito and Atsushi Yokota. Conversion of cholic acid and chenodeoxycholic acid into their 7-oxo derivatives by Bacteroides intestinalis AM-1isolated from human feces.
FEMS Microbiology Letters, 293: 263-270 (2009). >>PubMed
60. Ogami, Shinichi, Hijikata, Shoichi, Tsukahara, Tamostu, Mie, Yasuhiro, Matsuno, Toshihide, Morita, Naoki, Hara, Isao, Yamazaki, Koji, Inoue, Norio, Yokota, Atsushi, Hoshino, Tamotsu, Yoshimune, Kazuaki, Yumoto, Isao. A membrane-anchored cytochrome c-550 of alkaliphilic Bacillus clarkii K24-1U: Expression, molecular features and properties of redox potential.
Extremophiles, 13(3):491-504 (2009) >>PubMed
61. Murakami T, Maeda T, Yokota A, Wada M. Gene cloning and expression of pyridoxal 5'-phosphate-dependent L-threo-3-hydroxyaspartate dehydratase from Pseudomonas sp. T62, and characterization of the recombinant enzyme.
Journal of Biochemistry, 145(5):661-668 (2009) >>PubMed
62.Kikuchi H, Sakurai H, Nagura T, Aritsuka T, Tomita F, Yokota A. One-pot conversion of levan prepared from Serratia levanicum NN to difructose anhydride IV by Arthrobacter nicotinovorans levan fructotransferase.
Journal of Bioscience and Bioengineering, 109: 240-243 (2010).
>>PubMed
63.Sawada K, Zen-in S, Wada M, Yokota A. Metabolic changes in a pyruvate kinase gene deletion mutant of Corynebacterium glutamicum ATCC 13032.
Metabolic Engineering, 12: 401-407 (2010).
>>PubMed
64.Fukiya S, Sugiyama T, Kano Y, Yokota A. Characterization of an insertion sequence-like element ISBlo15
identified in a size-increased cryptic plasmid pBK283 harbored in
Bifidobacterium longum BK28.
Journal of Bioscience and Bioengineering, 110: 141-146 (2010).
>>PubMed
65.Suzuki T, Nishimukai M, Shinoki A, Taguchi H, Fukiya S, Yokota A, Saburi W, Yamamoto T, Hara H, Matsui H. Ingestion of epilactose, a non-digestible disaccharide, improves postgastrectomy osteopenia and anemia in rats through the promotion of intestinal calcium and iron absorption.
Journal of Agricultural and food chemistry, 58: 10787-10792 (2010).
>>PubMed
66.Maeda T, Takeda Y, Murakami T, Yokota A, Wada M. Purification, characterization and amino acid sequence of a novel enzyme, D-threo-3-hydroxyaspartate dehydratase, from Delftia sp. HT23.
Journal of Biochemistry, 148: 705-712 (2010).
>>PubMed
67.Kihira C, Hayashi Y, Azuma N, Noda S, Maeda S, Fukiya S, Wada M, Matsushita K, Yokota A. Alterations of glucose metabolism in Escherichia coli mutants defective in respiratory-chain enzymes.
Journal of Biotechnology, Article in Press.
>>PubMed
68.Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T, Ogura Y, Hayashi T, Yokota A. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats.
Gastroenterology, 141:1773–1781(2011).
>>PubMed
■著書（現在の研究に関連する主要な著書のみを示しました）
1. 横田 篤：「微生物と産業」，116-131（百瀬春生：「生物工学基礎コース 微生物工学」，丸善，東京）（1997）．
2. Yokota, S. Amachi and F. Tomita: Pyruvate, production using defective atpase activity. In The Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation, 2261-2268. (eds. M. C. Flickinger and S. W. Drew, John Wiley & Sons, New York, USA) (1999).
3. F. Tomita, A. Yokota, T. Kasai, H. Hara and K. Sayama: An efficient production of DFA III and its potential utility as a physiologically functional food. In Food for health in the Pacific rim, 353-362. (eds. J. R. Whitaker, N. F. Haard, C. F. Shoemaker and R. P. Singh, Food & Nutrition Press, Inc., Trumbull, Connecticut, USA) (1999).
4. 横田 篤，冨田房男：α-ケトグルタル酸（2-オキソグルタル酸）発酵，56-57（（財）バイオインダストリー協会発酵と代謝研究会編集，「発酵ハンドブック」，共立出版，東京）（2001）．>> Amazon
5. 横田 篤，冨田房男：ピルビン酸発酵，348-349（（財）バイオインダストリー協会発酵と代謝研究会編集，「発酵ハンドブック」，共立出版，東京）（2001）．>> Amazon
6. 冨田房男，横田 篤：Ｌ-リンゴ酸発酵，424-425（（財）バイオインダストリー協会発酵と代謝研究会編集，「発酵ハンドブック」，共立出版，東京）（2001）．>> Amazon
7. A. Yokota and N. D. Lindley: Central metabolism: Sugar uptake and conversion. In Handbook of Corynebacterium glutamicum: pp. 216-240. (eds. L. Eggeling and M. Bott, CRC Press, USA) (2005). >> Amazon
8. A. Yokota and M. Wada: Central Metabolism Enhancement using Defective F1-ATPase. In Encyclopedia of Industrial Biotechnology. (eds. Michael C. Flickinger, John Wiley & Sons, Inc. USA) (2009). >> Amazon
9.澤渡優喜, 横田 篤：乳酸菌の生育, 178-192（日本乳酸菌学会監修，「乳酸菌とビフィズス菌のサイエンス」, 京都大学学術出版会, 京都) (2010).
>> Amazon
10.横田 篤：胆汁酸， 240-250（日本乳酸菌学会監修，「乳酸菌とビフィズス菌のサイエンス」, 京都大学学術出版会, 京都） （2010）.
>> Amazon
11.S. Fukiya, T. Suzuki, Y. Kano, A. Yokota: Current status of Bifidobacterium gene manipulation technologies. In Lactic Acid Bacteria and Bifidobacteria: pp. 35-11. (eds. K. Sonomoto, A. Yokota, Caister Academic Press, Norfolk) (2011).
>> Amazon
12.A. Margolles, A. Yokota: Bile acid stress in lactic acid bacteria and bifidobacteria. In Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research: pp. 111-142. (eds. K. Sonomoto, A. Yokota, Caister Academic Press, Norfolk) (2011).
>> Amazon
■総説（現在の研究に関連する主要な総説のみを示しました）
1. 冨田房男，横田 篤：天然多糖からの微生物による有用オリゴ糖の生産．化学と生物，30(3)，170-175 (1992)．
>> Web site
2. 横田 篤，冨田房男：オリゴ糖の機能と生産に関する研究の最近の潮流．日本醸造協会誌，89(8)，626-633 (1994)．
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3. 横田 篤，冨田房男：エネルギー代謝変異株によるピルビン酸発酵の効率化．バイオサイエンスとインダストリー，53(5)，411-413 (1995)．
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4. 川崎公誠，横田 篤，冨田房男：トリプトファンの新しい生産法 トリプトファナーゼを高発現するピルビン酸生産性組換え大腸菌を利用．化学と生物，34(9)，569-570 (1996)．
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5. 横田 篤：エネルギー代謝変異による有用微生物の育種に関する研究．日本農芸化学会誌，71(1)，9-14 (1997)．
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6. 櫻井博章，横田 篤，冨田房男：イヌリン-新糖質資源としての展望．バイオサイエンスとインダストリー，55(1)， 25-29 (1997)．
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7. 横田 篤，関根寛直，冨田房男：コリネ型細菌をめぐる最近の話題(2) 電子伝達とエネルギー代謝 エネルギー代謝変異と中枢代謝の変化．バイオサイエンスとインダストリー，56(3)，29-31 (1998)．
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8. 横田 篤，冨田房男：エネルギーが欠乏しても糖代謝活性は亢進するメカニズムとは？ 大腸菌から明らかになった呼吸鎖酵素活性の上昇による細胞の「質的変化」，化学と生物，40，772-774（2002）．
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9. 横田 篤：腸内乳酸菌の新機能—胆汁酸取り込み活性の発見と生活習慣病予防プロバイオティクスへの応用．医学のあゆみ，207(10)，862-866，(2003)．
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10. 横田 篤，Peter Kurdi：腸内乳酸菌に対する胆汁酸の生育阻害機構のエネルギー代謝解析．生物工学会誌，82(5), 197-200（2004）．
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11. 横田 篤：腸内乳酸菌の胆汁酸取込み能とプロバイオティクス機能．バイオサイエンスとインダストリー，62(8)，23-26 (2004)．
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12. 横田 篤，山内宏昭，戸澤英男：「北海道産の超強力強力小麦粉を用いた新高付加価値食品の開発」コンソーシアム．バイオサイエンスとインダストリー，63(6)，55-57 (2005)．
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13. 澤渡優喜，横田 篤：新規小麦粉発酵食品の開発〜植物性乳酸菌を用いた発酵即席麺〜
Japanese Journal of Lactic Acid Bacteria, 16, 75-83 (2005).
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14. A. Dinoto, S. Fukiya, and A. Yokota. FISH-flow cytometry: a high-throughput molecular ecological analysis of intestinal microbiota. (Review)
Japanese Journal of Lactic Acid Bacteria, 17, 110-117 (2006).
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15. 横田篤：エネルギー代謝の改変による中枢代謝の活性化と有用物質発酵生産菌育種への応用．バイオサイエンスとインダストリー，65(6)，276-281 (2007)．
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16. 吹谷智，横田篤：新たな腸内細菌叢解析手法としてのFISH-フローサイトメトリー法．生化学，80(5), 421-425 (2008).
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17. 吹谷智，横田篤：急展開を見せる腸内細菌研究．大規模シークエンス解析により明らかになってきた腸内細菌叢の構造と機能．化学と生物，47(1), 11-13 (2009).
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