The
Sonoyama
Lab
Laboratory of Gut
Physiology, Graduate School of Life Science
Laboratory of Food
Biochemistry, Faculty of Agriculture
Contact
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-2023-
Ohsaka F,
Honma D, Kadota Y, Tochio T, Sonoyama K. Consumption of 1-kestose
upregulates microRNA-200 and -192/215 families in lamina propria
leukocytes of the murine large intestine. J Nutr Sci Vitaminol 2023; 69: 150-154.
Tatsuoka M, Shimada R, Ohsaka F, Sonoyama K. Administration of Bifidobacterium pseudolongum suppresses colonic serotonin increase and alleviates symptoms in dextran sodium sulfate-induced colitis mice. Biosci Microb Food Health 2023; 42: 186-194.
Sonoyama K, Ohsaka F. Role of microRNAs in the crosstalk between the gut microbiota and intestinal immune system (a review article). Biosci Microb Food Health 2023; 42: 222-228.
Tsuruta
T, Sonoyama K, Miyamoto T, Nguyen QD, Mizote A, Teraoka M, Nishino N.
Cyclic nigerosylnigerose attenuates high-fat diet-induced fat
deposition, colonic inflammation, and abnormal glucose metabolism and
modifies gut immunoglobulin A reactivity to commensal bacteria. Mol Nutr Food Res 2023; e2200389.
Tsukada A,
Okamatsu-Ogura Y, Futagawa E, Habu Y, Takahashi N, Kato-Suzuki M, Kato
Y, Ishizuka S, Sonoyama K, Kimura K. White adipose tissue undergoes
browning during preweaning period in association with microbiota
formation in mice. iScience 2023; 26: 107239.
Ohsaka F, Yamaguchi M,
Teshigahara Y, Yasui M, Kato E, Sonoyama K. Murine fecal microRNAs
alter the composition of cultured gut microbiota. Biochem Biophys Res Commun in press.
Shimada M, Kawase Y,
Sonoyama K, Ogura Y, Hayashi T, Yokota A, Fukiya S. Development of an
improved colonization system for human-derived Bifidobacterium longum subsp. longum in conventional mice through the feeding of raffinose or 1-kestose. Biosci Microb Food Health in press.
-2022-
Tatsuoka M, Osaki Y, Ohsaka F, Tsuruta T, Kadota Y, Tochio T, Hino S,
Morita T, Sonoyama K. Consumption of indigestible saccharides and
administration of Bifidobacterium pseudolongum reduce mucosal serotonin
in murine colonic mucosa. Br J Nutr 2022; 127: 513-525.
Seki M, Miwa A, Ohsaka F, Karatsu Y, Tsuruta T, Hino S,
Morita T, Sonoyama K. Local free fatty acids trigger the expression of
lipopolysaccharide-binding protein in murine white adipose tissue. Biosci Microb Food
Health 2022; 41: 54-65.
-2021-
Ohsaka F, Karatsu Y, Kadota Y, Tochio T, Takemura N, Sonoyama K. Gut
commensals suppress interleukin-2 production through
microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria
leukocytes of murine large intestine. Biochem Biophys Res Commun 2021; 534: 808-814.
Tsuruta T, Muhomah T, Sonoyama K, Nguyen QD, Takase Y, Nishijima A, Himoto S, Katsumata E, Nishino N. Aicda deficiency exacerbates high-fat diet-induced hyperinsulinemia but not gut dysbiosis in mice. Nutr Res 2021; 93: 15-26.
-2020-
Koguchi
H, Ishigami N, Sakanaka M, Yoshida K, Hiratou S, Shimada M, Fukiya S,
Sonoyama K, Yokota A. Application of recombinase-based in vivo expression technology to Bifidobacterium longum subsp. longum for identification of genes induced in the gastrointestinal tract of mice. Microorganisms 2020; 8: E410.
Udomsopagit T, Miwa A, Seki
M, Shimbori E, Kadota Y, Tochio T, Sonoyama K. Intestinal microbiota
transplantation reveals the role of microbiota in dietary regulation of
RegIIIƒÀ and RegIIIƒÁ expression in mouse intestine. Biochem Biophys Res Commun 2020; 529: 64-69.
Okumura M, Hamada A, Ohsaka F, Tsuruta T, Hira T, Sonoyama K.
Expression of serotonin receptor HTR4 in glucagon-like
peptide-1-positive enteroendocrine cells of the murine intestine. Pflügers Arch - Eur J Physiol 2020; 472: 1521-1532.
-2018-
Ohsaka F, Sonoyama K. Murine intestinal organoids resemble intestinal epithelium in their microRNA profiles. Biosci Biotechnol Biochem 2018; 82: 1560-1567.
Tomabechi
Y, Tsuruta T, Saito S, Wabitsch M, Sonoyama K. Extra-adrenal
glucocorticoids contribute to the postprandial increase of circulating
leptin in mice. J Cell Commun Signal 2018; 12: 433-439.
-2017-
Genda
T, Sasaki Y, Kondo T, Hino S, Nishimura N, Tsukahara T, Sonoyama K,
Morita T. Fructo-oligosaccharide-induced transient increases in cecal
immunoglobulin A concentrations in rats are associated with mucosal
inflammation in response to increased gut permeability. J Nutr 2017; 147: 1900-1908.
Aoki-Yoshida A, Saito S, Tsuruta T, Ohsumi A, Tsunoda H, Sonoyama K. Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro. Biochem Biophys Res Commun 2017; 489: 248-254.
-2016-
Aoki-Yoshida A, Saito S, Fukiya S, Aoki R, Takayama Y, Suzuki C, Sonoyama K. Lactobacillus rhamnosus GG increases Toll-like receptor 3 gene expression in murine small intestine ex vivo and in vivo. Benef Microbes 2016; 7: 421-429.
Tsuruta T, Saito S, Osaki Y, Hamada A, Aoki-Yoshida A, Sonoyama K. Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium. Biochem Biophys Res Commun 2016; 474: 161-167.
-2015-
Ishihara
R, Mizuno Y, Miwa A, Hamada A, Tsuruta T, Wabitsch M, Sonoyama K.
Intestinal epithelial cells promote secretion of leptin and adiponectin
in adipocytes. Biochem Biophys Res Commun 2015; 458: 362-368.
Asano M,
Yamamoto T, Tsuruta T, Nishimura N, Sonoyama K. Dual-labeling with
5-bromo-2'-deoxyuridine and 5-ethynyl-2'-deoxyuridine for estimation of
cell migration rate in the small intestinal epithelium. Dev Growth Differ 2015; 57: 68-73.
-2014-
Phoonsawat W, Aoki-Yoshida A, Tsuruta T, Sonoyama K. Adiponectin is partially associated with exosomes in mouse serum. Biochem Biophys Res Commun 2014; 448: 261-266.
Sahasakul Y, Takemura N, Sonoyama K. Gastric emptying is involved in lactobacilli colonization in mouse stomach. Br J Nutr 2014; 112: 408-415.
-2013-
Hino S, Sonoyama K, Bito H, Kawagishi H, Aoe S, Morita T. Ingestion of
low-methoxyl pectin stimulates small intestinal mucin secretion
irrespective of goblet cell proliferation and is characterized by
jejunum Muc2 up-regulation in rats. J Nutr 2013; 143: 34-40.
Okubo T,
Takemura N, Yoshida A, Sonoyama K. KK/Ta mice administered with Lactobacillus plantarum strain
No.14 have lower adiposity and higher insulin sensitivity. Biosci Microb Food
Health 2013; 32: 93-100.
-2012-
Sahasakul Y, Takemura N, Sonoyama K. Different impacts of purified and
nonpurified diets on the microbiota and Toll-like receptors in mouse
stomach. Biosci
Biotechnol Biochem 2012; 76: 1728-1732.
Sugita R, Hata E, Miki A, Andoh R, Umeda C, Takemura N, Sonoyama K. Gut
colonization by Candida albicans
inhibits the induction of humoral immune tolerance to dietary antigen
in BALB/c mice. Biosci Microb Food
Health
2012; 31: 77-84.
Ozawa K, Fujiwara R, Watanabe K, Sonoyama K. Persistence of orally
administered Lactobacillus
strains in the gut of infant mice. Biosci Microb Food
Health
2012; 31:
85-91.
Sakurai A,
Yamaguchi N, Sonoyama K. Cell wall polysaccharides of Candida albicans induce mast cell
degranulation in the gut. Biosci Microb Food
Health2012;
31: 67-70.
Nakamura Y,
Sonoyama K. Reduced expression of polymeric immunoglobulin
receptors in the intestine of young rats fed a fiber-free diet. Biosci Microb Food
Health
2012; 31: 51-58.
Hino S, Takemura N, Sonoyama K, Morita A, Kawagishi H, Aoe S, Morita T.
Small intestinal goblet cell proliferation induced by ingestion of
soluble and insoluble dietary fiber is characterized by an inrease in
sialylated mucins in rats. J Nutr 2012;
142: 1429-1436.
-2011-
Ito H,
Takemura N, Sonoyama
K, Kawagishi H, Topping D, Conlon M, Morita T. Degree of polymerization
of inulin-type fructans differentially affects number of lactic
acid-bacteria, mucosal immune functions and immunoglobulin A secretion
in the rat cecum. J
Agric Food Chem 2011; 59: 5771-5778.
Sonoyama K, Miki A, Sugita R, Goto
H, Nakata M, Yamaguchi N. Gut
colonization by Candida albicans
aggravates inflammation in
the gut and extra-gut tissues in mice.
Med
Mycol 2011; 49: 237-247.
-2010-
Goto H,
Takemura N,
Ogasawara T, Sasajima N, Watanabe J, Ito H,
Morita T, Sonoyama K. Effects of fructo-oligosaccharide on DSS-Induced
colitis differ in mice fed nonpurified and purified diets. J
Nutr 2010; 140; 2121-2127.
Takemura N, Hagio M, Ishizuka S,
Ito H, Morita T, Sonoyama K. Inulin
prolongs survival of intragastrically administered Lactobacillus
plantarum No. 14 in
the gut of mice fed a high-fat diet. J
Nutr 2010; 140: 1963-1969.
Fujiwara R, Sasajima N, Takemura N,
Ozawa K, Nagasaka Y, Okubo T,
Sahasakul Y, Watanabe J, Sonoyama K. 2,4-dinitrofluorobenzene-induced
contact hypersensitivity response in NC/Nga mice fed
fructo-oligosaccharide. J
Nutr Sci Vitaminol 2010;
56: 260-265.
Takemura N, Okubo T, Sonoyama K. Lactobacillus
plantarum strain No. 14
reduces adipocyte size in mice fed
high-fat diet. Exp
Biol Med (Maywood) 2010;
235: 849-856.
Takemura N, Ozawa K, Kimura N,
Watanabe J, Sonoyama K. Inulin-type
fructans stimulate the growth of exogenously administered Lactobacillus
plantarum No.14 in the mouse gastrointestinal tract. Biosci
Biotechnol
Biochem 2010; 74: 375-381.
Sasajima N, Ogasawara T, Takemura
N, Fujiwara R, Watanabe J, Sonoyama
K. Role of intestinal Bifidobacterium
pseudolongum in dietary
fructo-oligosaccharide inhibition of
2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice. Br
J Nutr 2010;
103: 539-548.
Fujiwara R, Takemura N, Watanabe J,
Sonoyama K. Maternal consumption of
fructo-oligosaccharide diminishes the severity of skin inflammation in
offspring of NC/Nga mice. Br
J Nutr
2010; 103: 530-538.
Sonoyama K, Ogasawara T, Goto H,
Yoshida T, Takemura N, Fujiwara R,
Watanabe J, Ito H, Morita T, Tokunaga Y, Yanagihara T. Comparison of
gut microbiota and allergic reactions in BALB/c mice fed different
cultivars of rice. Br
J Nutr 2010; 103: 218-226.
Watanabe J, Fujiwara R, Sasajima N,
Ito S, Sonoyama K. Administration
of antibiotics during infancy promoted the development of atopic
dermatitis-like skin lesions in NC/Nga mice. Biosci
Biotechnol
Biochem 2010; 74: 358-363.
-2009-
Sonoyama K, Fujiwara R, Takemura N,
Ogasawara T, Watanabe J, Ito H,
Morita T. Response of gut microbiota to fasting and hibernation in
Syrian hamsters. Appl
Environ Microbiol 2009; 75:
6451-6456.
Miki A, Sugita R, Watanabe J, Ito
H, Morita T, Sonoyama K. Elimination
mechanism of Candida albicans in the colon of BALB/c mice by dietary
fructo-oligosaccharide. Dyn
Biochem Proc
Biotechnol Mol Biol 2009;
3: 85-89.
Ito H, Satsukawa M, Arai E,
Sugiyama K, Sonoyama K, Kiriyama S, Morita
T. Soluble fiber viscosity affects both goblet cell number and small
intestine mucin secretion in rats. J
Nutr 2009;
139: 1640-1677.
-2008-
Pirapatdit S, Kishino E, Fujita K,
Hashimoto H, Mori S, Saito S, Sato
T, Watanabe J, Sonoyama K. Dietary ƒ¿-linked galacto-oligosaccharide
suppresses ovalbumin-induced allergic peritonitis in BALB/c mice. Biosci
Biotechnol
Biochem 2008; 72: 1901-1907.
Watanabe J, Sasajima N, Aramaki A,
Sonoyama, K. Consumption of
fructo-oligosaccharide reduces 2,4-dinitrofluorobenzene-induced contact
hypersensitivity in mice. Br
J Nutr 2008;
100: 339-346.
Fujiwara R, Watanabe J, Sonoyama K.
Assessing changes in composition of
intestinal microbiota in neonatal BALB/c mice through cluster analysis
of molecular markers. Br
J Nutr 2008;
99: 1174-1177.
-2007-
-2006-
Yamaguchi N, Sugita R, Miki A,
Takemura N, Kawabata J, Watanabe J,
Sonoyama K. Gastrointestinal Candida
colonisation promotes
sensitisation against food antigens by affecting
the mucosal barrier in mice.
Gut
2006; 55:
954-960.
-2005-
Sonoyama K, Watanabe H, Watanabe J,
Yamaguchi N, Yamashita A, Hashimoto
H, Kikuchi E, Fujita K, Okada M, Mori S, Kitahata S, Kawabata J.
Allergic airway eosinophilia is suppressed in ovalbumin-sensitized
Brown Norway rats fed raffinose and a-linked galactooligosaccharide. J
Nutr 2005;
135: 538-543.
Umeda C, Sonoyama K, Yamaguchi N,
Saito R, Akashi K, Motoshima H,
Kawabata J. Oral administration of freeze-dried kefir reduces
intestinal permeation of and oral sensitization to ovalbumin in mice. Biosci
Biotechnol
Biochem 2005; 69: 249-251.
Yamaguchi N, Sonoyama K, Kikuchi H,
Nagura T, Aritsuka T, Kawabata J.
Gastric colonization of Candida albicans differs in mice fed a
commercial stock diet and a purified diet. J
Nutr 2005;
135: 109-115.
-2004-
Watanabe J, Tanabe S, Watanabe M,
Shinmoto H, Sonoyama K. The
production of hypoallergenic wheat flour and the analysis of its
allergy suppressive effects. Biofactors 2004;
22: 295-297.
Watanabe H, Sonoyama K, Watanabe J,
Yamaguchi N, Kikuchi H, Nagura T,
Aritsuka T, Fukumoto K, Kasai T. Reduction of allergic airway
eosinophilia by dietary raffinose in Brown Norway rats. Br
J Nutr 2004;
92: 247-255.
Watanabe J, Fukumoto K, Fukushi E,
Sonoyama K, Kawabata J. Isolation of
tryptophan as an inhibitor of ovalbumin permeation and analysis of its
suppressive effect on oral sensitization. Biosci
Biotechnol
Biochem 2004; 68: 59-65.
Hashimoto H, Yamashita A, Fujita K,
Okada M, Mori S, Sonoyama K,
Kitahata S. Enzymatic synthesis of ƒ¿-linked galactooligosaccharide
(ƒ¿-GOS) and its functions. (Proceedings of the Symposium on Amylases
and Related Enzymes, 2003) J
Appl Glycosci 2004;
51: 169-176.
-2003-
Saitoh R, Yamaguchi N, Sonoyama K,
Kawabata J. Effect of enzymatic
modification of dietary wheat flour for reducing its allergenicity on
oral sensitization to and intestinal absorption of ovalbumin. Biosci
Biotechnol
Biochem 2003; 67: 2483-2485.
Pholnukulkit P, Sonoyama K,
Kawabata J. Activin A induces
phosphorylation of Smad2 but not complex formation of Smad2 with Smad4
in human colon cancer cell line HT-29. Biosci
Biotechnol
Biochem 2003; 67: 2042-2044.
Sonoyama K, Pholnukulkit P, Toyoda
M, Rutatip S, Kasai T. Upregulation
of activin A gene by butyrate in human colon cancer cell lines. Am
J Physiol
(Gastrointestinal and Liver Physiology) 2003; 284: G989-G995.
Tanabe S, Tesaki S, Watanabe J,
Fukushi E, Sonoyama K, Kawabata J.
Isolation and structural elucidation of a peptide derived from edam
cheese that inhibits ƒÀ-lactoglobulin transport. J
Dairy Sci 2003;
86: 464-468.
-2002-
Tesaki S, Watanabe J, Tanabe S,
Sonoyama K, Fukushi E, Kawabata J,
Watanabe M. An active compound against allergen absorption in
hypoallergenic wheat flour produced by enzymatic modification. Biosci
Biotechnol
Biochem 2002; 66: 1930-1935.
-2001-
Fukushima M, Shimada K, Ohashi T,
Saitoh H, Sonoyama K, Sekikawa M,
Nakano M. Investigation of gene expressions related to cholesterol
metabolism in rats fed diets enriched in n-6 or n-3 fatty acid with a
cholesterol after long-term feeding using quantitative-competitive
RT-PCR analysis. J
Nutr Sci Vitaminol 2001;
47: 228-235.
Watanabe J, Tanabe S, Sonoyama K,
Kuroda M, Watanabe M. IgE-reactive 60
kDa glycoprotein occurring in wheat flour. Biosci
Biotechnol
Biochem 2001; 65: 2102-2105.
Watanabe J, Tanabe S, Watanabe M,
Kasai T, Sonoyama K. Consumption of
hypoallergenic flour prevents gluten-induced airway inflammation in
Brown Norway rats. Biosci
Biotechnol Biochem 2001; 65:
1729-1735.
Fukushima M, Ohashi T, Fujiwara Y,
Sonoyama K, Nakano M.
Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and
enokitake (Flammulina velutipes)
fiber in rats. Exp
Biol Med (Maywood) 2001;
226: 758-765.
Fukushima M, Ohashi T, Ohno S,
Saitoh H, Sonoyama K, Shimada K,
Sekikawa M, Nakano M. Effects of diets enriched in n-6 or n-3 fatty
acids on cholesterol metabolism in older rats chronically fed a
cholesterol-enriched diet. Lipids
2001;
36: 261-266.
Fukushima M, Ohashi T, Kojima M,
Ohba K, Shimizu H, Sonoyama K, Nakano
M. Low density lipoprotein receptor mRNA in rat liver is affected by
resistant starch of beans. Lipids 2001; 36:
129-134.
-2000-
Watanabe M, Watanabe J, Sonoyama K,
Tanabe S. Novel method for
producing hypoallergenic wheat flour by enzymatic fragmentation of the
constituent allergens and its application to food processing. Biosci
Biotechnol
Biochem 2000; 64: 2663-2667.
Fukushima M, Nakano M, Morii Y,
Ohashi T, Fujiwara Y, Sonoyama K.
Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar
beet fiber. J
Nutr
2000; 130: 2151-2156.
Sonoyama K, Fujiwara R, Kasai T.
Non-effect of hexamethonium, a
ganglionic blocker, on the response of ileal apolipoprotein A-IV mRNA
following a massive small bowel resection in rats. Biosci
Biotechnol
Biochem 2000; 64: 1282-1284.
Sonoyama K, Tajima K, Fujiwara R,
Kasai T. Intravenous infusion of
hexamethonium and atropine but not propranolol diminishes
apolipoprotein A-IV gene expression in rat ileum. J
Nutr 2000;
130: 637-641.
Sonoyama K, Suzuki K, Kasai T.
Peptide YY stimulates the expression of
apolipoprotein A-IV gene in Caco-2 intestinal cells. Proc
Soc Exp Biol Med
2000; 223: 270-275 (2000)
Sonoyama K, Rutatip S, Kasai T.
Gene expression of activin, activin
receptors, and follistatin in intestinal epithelial cells. Am
J Physiol
(Gastrointestinal and Liver Physiology) 2000; 278: G89-G97.
-1999-
Miyakawa R, Sonoyama K, Kasai T.
Apolipoprotein B mRNA editing in the
liver and small intestine of rats fed on beet fiber, soy protein, and
fish oil. Biosci
Biotechnol
Biochem 1999; 63:
1315-1317.
-1998-
-1997-
Sonoyama K, Aoyama Y. Different
responses of apolipoprotein A-I, A-IV
and B gene expression during intestinal adaptation to a massive small
bowel resection in rats. Biosci
Biotechnol
Biochem 1997; 61: 1810-1813.
Ishizuka S, Sonoyama K, Kasai T.
Changes in the number and apoptosis of
epithelial cells in the colorectum of wheat bran-fed rats soon after
administering 1,2-dimethylhydrazine. Biosci
Biotechnol
Biochem 1997; 61: 1337-1341.
Sonoyama K, Fujiwara R, Aoyama Y.
Stimulating effect of Ileal
pancreaticobiliary secretion on ileal apolipoprotein A-IV mRNA
expression in fasted rats. Biosci
Biotechnol
Biochem 1997; 61: 887-889.
-1996-
Sonoyama K, Nakamura Y, Kiriyama S,
Niki R. Upregulation of
apolipoprotein A-IV gene expression in residual ileum after massive
small bowel resection requires the biliary secretion in rats. Proc
Soc Exp Biol Med
1996; 211: 273-280.
-1995-
Sonoyama K, Kiriyama S, Niki R.
Adaptive response of apolipoprotein A-I
and A-IV mRNA in residual ileum after massive small bowel resection in
rats. J
Nutr Sci
Vitaminol 1995; 41: 253-264.
Sonoyama K, Kiriyama S, Niki R.
Expression of apolipoprotein A-I mRNA
in liver and intestine of cecectomized rats fed beet fiber. J
Nutr Biochem
1995; 6: 380-384.
Sonoyama K, Nishikawa H, Kiriyama
S, Niki R. Apolipoprotein mRNA in
liver and intestine of rats is affected by dietary beet fiber or
cholestyramine. J
Nutr 1995; 125: 13-19.
-1994-
Ishizuka S, Sonoyama K, Niki R.
Food deprivation increases apoptotic
cell counts induced by 1,2-dimethylhydrazine in rat descending colonic
and rectal crypts. J
Nutr Sci Vitaminol 1994; 40:
363-369.
Sonoyama K, Nishikawa H, Kiriyama
S, Niki R. Bile diversion lowers
apolipoprotein A-I and A-IV mRNA levels in rat ileum. J
Nutr Sci Vitaminol
1994; 40: 343-352.
Sonoyama K, Kiriyama S, Niki R.
Effect of dietary protein level on
intestinal aminopeptidase activity and mRNA level in rats. J
Nutr Biochem
1994; 5: 291-297.
Sonoyama K, Nishikawa H, Kiriyama
S, Niki R. Cholestyramine and a
fat-free diet lower apolipoprotein A-IV mRNA in jejunum and
cholestyramine lowers apolipoprotein A-I mRNA in ileum of rats. J
Nutr 1994;
124: 621-627.
-1993-
Sonoyama K, Kiriyama S, Niki R.
Cholestyramine and bile diversion lower
the aminopeptidase activity in the intestinal brush border membrane of
rats. J
Nutr Sci
Vitaminol 1993; 39: 617-625.