Hokkaido UniversityThe Sonoyama Lab
Laboratory of Gut Physiology, Graduate School of Life Science
Laboratory of Food Biochemistry, Faculty of Agriculture


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-2021-

Ohsaka F, Karatsu Y, Kadota Y, Tochio T, Takemura N, Sonoyama K. Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.
Biochem Biophys Res Commun 2021; 534: 808-814.

Tatsuoka M, Osaki Y, Ohsaka F, Tsuruta T, Kadota Y, Tochio T, Hino S, Morita T, Sonoyama K. Consumption of indigestible saccharides and administration of Bifidobacterium pseudolongum reduce mucosal serotonin in murine colonic mucosa. Br J Nutr in press.

Tsuruta T, Muhomah T, Sonoyama K, Nguyen QD, Takase Y, Nishijima A, Himoto S, Katsumata E, Nishino N. Aicda deficiency exacerbates high-fat diet-induced hyperinsulinemia but not gut dysbiosis in mice. Nutr Res in press.  


-2020-

Koguchi H, Ishigami N, Sakanaka M, Yoshida K, Hiratou S, Shimada M, Fukiya S, Sonoyama K, Yokota A. Application of recombinase-based in vivo expression technology to Bifidobacterium longum subsp. longum for identification of genes induced in the gastrointestinal tract of mice. Microorganisms 2020; 8: E410.

Udomsopagit T, Miwa A, Seki M, Shimbori E, Kadota Y, Tochio T, Sonoyama K.  Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIII and RegIII expression in mouse intestine. Biochem Biophys Res Commun 2020; 529: 64-69.

Okumura M, Hamada A, Ohsaka F, Tsuruta T, Hira T, Sonoyama K. Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine. Pflügers Arch - Eur J Physiol 2020; 472: 1521-1532.


-2018-

Ohsaka F, Sonoyama K. Murine intestinal organoids resemble intestinal epithelium in their microRNA profiles. Biosci Biotechnol Biochem 2018; 82: 1560-1567.

Tomabechi Y, Tsuruta T, Saito S, Wabitsch M, Sonoyama K. Extra-adrenal glucocorticoids contribute to the postprandial increase of circulating leptin in mice. J Cell Commun Signal 2018; 12: 433-439.


-2017-

Genda T, Sasaki Y, Kondo T, Hino S, Nishimura N, Tsukahara T, Sonoyama K, Morita T. Fructo-oligosaccharide-induced transient increases in cecal immunoglobulin A concentrations in rats are associated with mucosal inflammation in response to increased gut permeability. J Nutr 2017; 147: 1900-1908.

Aoki-Yoshida A, Saito S, Tsuruta T, Ohsumi A, Tsunoda H, Sonoyama K. Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro. Biochem Biophys Res Commun 2017; 489: 248-254.



-2016-

Aoki-Yoshida A, Saito S, Fukiya S, Aoki R, Takayama Y, Suzuki C, Sonoyama K. Lactobacillus rhamnosus GG increases Toll-like receptor 3 gene expression in murine small intestine ex vivo and in vivo. Benef Microbes 2016; 7: 421-429.

Tsuruta T, Saito S, Osaki Y, Hamada A, Aoki-Yoshida A, Sonoyama K. Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium. Biochem Biophys Res Commun 2016; 474: 161-167.


-2015-

Ishihara R, Mizuno Y, Miwa A, Hamada A, Tsuruta T, Wabitsch M, Sonoyama K. Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes. Biochem Biophys Res Commun 2015; 458: 362-368.

Asano M, Yamamoto T, Tsuruta T, Nishimura N, Sonoyama K. Dual-labeling with 5-bromo-2'-deoxyuridine and 5-ethynyl-2'-deoxyuridine for estimation of cell migration rate in the small intestinal epithelium. Dev Growth Differ 2015; 57: 68-73.



-2014-

Phoonsawat W, Aoki-Yoshida A, Tsuruta T, Sonoyama K. Adiponectin is partially associated with exosomes in mouse serum. Biochem Biophys Res Commun 2014; 448: 261-266.

Sahasakul Y, Takemura N, Sonoyama K. Gastric emptying is involved in lactobacilli colonization in mouse stomach. Br J Nutr 2014; 112: 408-415.


-2013-

Hino S, Sonoyama K, Bito H, Kawagishi H, Aoe S, Morita T. Ingestion of low-methoxyl pectin stimulates small intestinal mucin secretion irrespective of goblet cell proliferation and is characterized by jejunum Muc2 up-regulation in rats.
J Nutr 2013; 143: 34-40.

Okubo T, Takemura N, Yoshida A, Sonoyama K. KK/Ta mice administered with Lactobacillus plantarum strain No.14 have lower adiposity and higher insulin sensitivity. Biosci Microb Food Health in press.2013; 32: 93-100.


-2012-

Sahasakul Y, Takemura N, Sonoyama K. Different impacts of purified and nonpurified diets on the microbiota and Toll-like receptors in mouse stomach. Biosci Biotechnol Biochem 2012; 76: 1728-1732.

Sugita R, Hata E, Miki A, Andoh R, Umeda C, Takemura N, Sonoyama K. Gut colonization by Candida albicans inhibits the induction of humoral immune tolerance to dietary antigen in BALB/c mice.
Biosci Microb Food Health 2012; 31: 77-84.

Ozawa K, Fujiwara R, Watanabe K, Sonoyama K. Persistence of orally administered Lactobacillus strains in the gut of infant mice.
Biosci Microb Food Health 2012; 31: 85-91.

Sakurai A, Yamaguchi N, Sonoyama K. Cell wall polysaccharides of Candida albicans induce mast cell degranulation in the gut. Biosci Microb Food Health2012; 31: 67-70.

Nakamura Y, Sonoyama K. Reduced expression of polymeric immunoglobulin receptors in the intestine of young rats fed a fiber-free diet. Biosci Microb Food Health 2012; 31: 51-58.

Hino S, Takemura N, Sonoyama K, Morita A, Kawagishi H, Aoe S, Morita T. Small intestinal goblet cell proliferation induced by ingestion of soluble and insoluble dietary fiber is characterized by an inrease in sialylated mucins in rats. J Nutr 2012; 142: 1429-1436.



-2011-

Ito H, Takemura N, Sonoyama K, Kawagishi H, Topping D, Conlon M, Morita T. Degree of polymerization of inulin-type fructans differentially affects number of lactic acid-bacteria, mucosal immune functions and immunoglobulin A secretion in the rat cecum. J Agric Food Chem 2011; 59: 5771-5778.

Sonoyama K, Miki A, Sugita R, Goto H, Nakata M, Yamaguchi N. Gut colonization by
Candida albicans
aggravates inflammation in the gut and extra-gut tissues in mice. Med Mycol 2011; 49: 237-247.


-2010-

Goto H, Takemura N, Ogasawara T, Sasajima N, Watanabe J, Ito H, Morita T, Sonoyama K. Effects of fructo-oligosaccharide on DSS-Induced colitis differ in mice fed nonpurified and purified diets. J Nutr 2010; 140; 2121-2127.

Takemura N, Hagio M, Ishizuka S, Ito H, Morita T, Sonoyama K. Inulin prolongs survival of intragastrically administered Lactobacillus plantarum No. 14 in the gut of mice fed a high-fat diet. J Nutr 2010; 140: 1963-1969.


Fujiwara R, Sasajima N, Takemura N, Ozawa K, Nagasaka Y, Okubo T, Sahasakul Y, Watanabe J, Sonoyama K. 2,4-dinitrofluorobenzene-induced contact hypersensitivity response in NC/Nga mice fed fructo-oligosaccharide. J Nutr Sci Vitaminol 2010; 56: 260-265.

Takemura N, Okubo T, Sonoyama K. Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Exp Biol Med (Maywood) 2010; 235: 849-856.

Takemura N, Ozawa K, Kimura N, Watanabe J, Sonoyama K. Inulin-type fructans stimulate the growth of exogenously administered Lactobacillus plantarum No.14 in the mouse gastrointestinal tract. Biosci Biotechnol Biochem 2010; 74: 375-381.

Sasajima N, Ogasawara T, Takemura N, Fujiwara R, Watanabe J, Sonoyama K. Role of intestinal Bifidobacterium pseudolongum in dietary fructo-oligosaccharide inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice. Br J Nutr 2010; 103: 539-548.

Fujiwara R, Takemura N, Watanabe J, Sonoyama K. Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC/Nga mice. Br J Nutr 2010; 103: 530-538.

Sonoyama K, Ogasawara T, Goto H, Yoshida T, Takemura N, Fujiwara R, Watanabe J, Ito H, Morita T, Tokunaga Y, Yanagihara T. Comparison of gut microbiota and allergic reactions in BALB/c mice fed different cultivars of rice. Br J Nutr 2010; 103: 218-226.

Watanabe J, Fujiwara R, Sasajima N, Ito S, Sonoyama K. Administration of antibiotics during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice. Biosci Biotechnol Biochem 2010; 74: 358-363.


-2009-

Sonoyama K, Fujiwara R, Takemura N, Ogasawara T, Watanabe J, Ito H, Morita T. Response of gut microbiota to fasting and hibernation in Syrian hamsters.
Appl Environ Microbiol 2009; 75: 6451-6456.

Miki A, Sugita R, Watanabe J, Ito H, Morita T, Sonoyama K. Elimination mechanism of Candida albicans in the colon of BALB/c mice by dietary fructo-oligosaccharide. Dyn Biochem Proc Biotechnol Mol Biol 2009; 3: 85-89.

Ito H, Satsukawa M, Arai E, Sugiyama K, Sonoyama K, Kiriyama S, Morita T. Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats. J Nutr 2009; 139: 1640-1677.


-2008-

Pirapatdit S, Kishino E, Fujita K, Hashimoto H, Mori S, Saito S, Sato T, Watanabe J, Sonoyama K. Dietary -linked galacto-oligosaccharide suppresses ovalbumin-induced allergic peritonitis in BALB/c mice.
Biosci Biotechnol Biochem 2008; 72: 1901-1907.

Watanabe J, Sasajima N, Aramaki A, Sonoyama, K. Consumption of fructo-oligosaccharide reduces 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice. Br J Nutr 2008; 100: 339-346.

Fujiwara R, Watanabe J, Sonoyama K. Assessing changes in composition of intestinal microbiota in neonatal BALB/c mice through cluster analysis of molecular markers. Br J Nutr 2008; 99: 1174-1177.


-2007-


-2006-

Yamaguchi N, Sugita R, Miki A, Takemura N, Kawabata J, Watanabe J, Sonoyama K. Gastrointestinal
Candida
colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice. Gut 2006; 55: 954-960.


-2005-

Sonoyama K, Watanabe H, Watanabe J, Yamaguchi N, Yamashita A, Hashimoto H, Kikuchi E, Fujita K, Okada M, Mori S, Kitahata S, Kawabata J. Allergic airway eosinophilia is suppressed in ovalbumin-sensitized Brown Norway rats fed raffinose and a-linked galactooligosaccharide.
J Nutr 2005; 135: 538-543.

Umeda C, Sonoyama K, Yamaguchi N, Saito R, Akashi K, Motoshima H, Kawabata J. Oral administration of freeze-dried kefir reduces intestinal permeation of and oral sensitization to ovalbumin in mice. Biosci Biotechnol Biochem 2005; 69: 249-251.

Yamaguchi N, Sonoyama K, Kikuchi H, Nagura T, Aritsuka T, Kawabata J. Gastric colonization of Candida albicans differs in mice fed a commercial stock diet and a purified diet. J Nutr 2005; 135: 109-115.


-2004-

Watanabe J, Tanabe S, Watanabe M, Shinmoto H, Sonoyama K. The production of hypoallergenic wheat flour and the analysis of its allergy suppressive effects.
Biofactors 2004; 22: 295-297.

Watanabe H, Sonoyama K, Watanabe J, Yamaguchi N, Kikuchi H, Nagura T, Aritsuka T, Fukumoto K, Kasai T. Reduction of allergic airway eosinophilia by dietary raffinose in Brown Norway rats. Br J Nutr 2004; 92: 247-255.

Watanabe J, Fukumoto K, Fukushi E, Sonoyama K, Kawabata J. Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization. Biosci Biotechnol Biochem 2004; 68: 59-65.

Hashimoto H, Yamashita A, Fujita K, Okada M, Mori S, Sonoyama K, Kitahata S. Enzymatic synthesis of -linked galactooligosaccharide (-GOS) and its functions. (Proceedings of the Symposium on Amylases and Related Enzymes, 2003) J Appl Glycosci 2004; 51: 169-176.


-2003-

Saitoh R, Yamaguchi N, Sonoyama K, Kawabata J. Effect of enzymatic modification of dietary wheat flour for reducing its allergenicity on oral sensitization to and intestinal absorption of ovalbumin.
Biosci Biotechnol Biochem 2003; 67: 2483-2485.

Pholnukulkit P, Sonoyama K, Kawabata J. Activin A induces phosphorylation of Smad2 but not complex formation of Smad2 with Smad4 in human colon cancer cell line HT-29. Biosci Biotechnol Biochem 2003; 67: 2042-2044.

Sonoyama K, Pholnukulkit P, Toyoda M, Rutatip S, Kasai T. Upregulation of activin A gene by butyrate in human colon cancer cell lines. Am J Physiol (Gastrointestinal and Liver Physiology) 2003; 284: G989-G995.

Tanabe S, Tesaki S, Watanabe J, Fukushi E, Sonoyama K, Kawabata J. Isolation and structural elucidation of a peptide derived from edam cheese that inhibits -lactoglobulin transport. J Dairy Sci 2003; 86: 464-468.


-2002-

Tesaki S, Watanabe J, Tanabe S, Sonoyama K, Fukushi E, Kawabata J, Watanabe M. An active compound against allergen absorption in hypoallergenic wheat flour produced by enzymatic modification.
Biosci Biotechnol Biochem 2002; 66: 1930-1935.


-2001-

Fukushima M, Shimada K, Ohashi T, Saitoh H, Sonoyama K, Sekikawa M, Nakano M. Investigation of gene expressions related to cholesterol metabolism in rats fed diets enriched in n-6 or n-3 fatty acid with a cholesterol after long-term feeding using quantitative-competitive RT-PCR analysis.
J Nutr Sci Vitaminol 2001; 47: 228-235.

Watanabe J, Tanabe S, Sonoyama K, Kuroda M, Watanabe M. IgE-reactive 60 kDa glycoprotein occurring in wheat flour. Biosci Biotechnol Biochem 2001; 65: 2102-2105.

Watanabe J, Tanabe S, Watanabe M, Kasai T, Sonoyama K. Consumption of hypoallergenic flour prevents gluten-induced airway inflammation in Brown Norway rats. Biosci Biotechnol Biochem 2001; 65: 1729-1735.

Fukushima M, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood) 2001; 226: 758-765.

Fukushima M, Ohashi T, Ohno S, Saitoh H, Sonoyama K, Shimada K, Sekikawa M, Nakano M. Effects of diets enriched in n-6 or n-3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet. Lipids 2001; 36: 261-266.

Fukushima M, Ohashi T, Kojima M, Ohba K, Shimizu H, Sonoyama K, Nakano M. Low density lipoprotein receptor mRNA in rat liver is affected by resistant starch of beans. Lipids 2001; 36: 129-134.


-2000-

Watanabe M, Watanabe J, Sonoyama K, Tanabe S. Novel method for producing hypoallergenic wheat flour by enzymatic fragmentation of the constituent allergens and its application to food processing.
Biosci Biotechnol Biochem 2000; 64: 2663-2667.

Fukushima M, Nakano M, Morii Y, Ohashi T, Fujiwara Y, Sonoyama K. Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar beet fiber. J Nutr 2000; 130: 2151-2156.

Sonoyama K, Fujiwara R, Kasai T. Non-effect of hexamethonium, a ganglionic blocker, on the response of ileal apolipoprotein A-IV mRNA following a massive small bowel resection in rats. Biosci Biotechnol Biochem 2000; 64: 1282-1284.

Sonoyama K, Tajima K, Fujiwara R, Kasai T. Intravenous infusion of hexamethonium and atropine but not propranolol diminishes apolipoprotein A-IV gene expression in rat ileum. J Nutr 2000; 130: 637-641.

Sonoyama K, Suzuki K, Kasai T. Peptide YY stimulates the expression of apolipoprotein A-IV gene in Caco-2 intestinal cells. Proc Soc Exp Biol Med 2000; 223: 270-275 (2000)

Sonoyama K, Rutatip S, Kasai T. Gene expression of activin, activin receptors, and follistatin in intestinal epithelial cells. Am J Physiol (Gastrointestinal and Liver Physiology) 2000; 278: G89-G97.


-1999-

Miyakawa R, Sonoyama K, Kasai T. Apolipoprotein B mRNA editing in the liver and small intestine of rats fed on beet fiber, soy protein, and fish oil.
Biosci Biotechnol Biochem 1999; 63: 1315-1317.


-1998-


-1997-

Sonoyama K, Aoyama Y. Different responses of apolipoprotein A-I, A-IV and B gene expression during intestinal adaptation to a massive small bowel resection in rats.
Biosci Biotechnol Biochem 1997; 61: 1810-1813.

Ishizuka S, Sonoyama K, Kasai T. Changes in the number and apoptosis of epithelial cells in the colorectum of wheat bran-fed rats soon after administering 1,2-dimethylhydrazine. Biosci Biotechnol Biochem 1997; 61: 1337-1341.

Sonoyama K, Fujiwara R, Aoyama Y. Stimulating effect of Ileal pancreaticobiliary secretion on ileal apolipoprotein A-IV mRNA expression in fasted rats. Biosci Biotechnol Biochem 1997; 61: 887-889.


-1996-

Sonoyama K, Nakamura Y, Kiriyama S, Niki R. Upregulation of apolipoprotein A-IV gene expression in residual ileum after massive small bowel resection requires the biliary secretion in rats.
Proc Soc Exp Biol Med 1996; 211: 273-280.


-1995-

Sonoyama K, Kiriyama S, Niki R. Adaptive response of apolipoprotein A-I and A-IV mRNA in residual ileum after massive small bowel resection in rats.
J Nutr Sci Vitaminol 1995; 41: 253-264.

Sonoyama K, Kiriyama S, Niki R. Expression of apolipoprotein A-I mRNA in liver and intestine of cecectomized rats fed beet fiber. J Nutr Biochem 1995; 6: 380-384.

Sonoyama K, Nishikawa H, Kiriyama S, Niki R. Apolipoprotein mRNA in liver and intestine of rats is affected by dietary beet fiber or cholestyramine. J Nutr 1995; 125: 13-19.


-1994-

Ishizuka S, Sonoyama K, Niki R. Food deprivation increases apoptotic cell counts induced by 1,2-dimethylhydrazine in rat descending colonic and rectal crypts.
J Nutr Sci Vitaminol 1994; 40: 363-369.

Sonoyama K, Nishikawa H, Kiriyama S, Niki R. Bile diversion lowers apolipoprotein A-I and A-IV mRNA levels in rat ileum. J Nutr Sci Vitaminol 1994; 40: 343-352.

Sonoyama K, Kiriyama S, Niki R. Effect of dietary protein level on intestinal aminopeptidase activity and mRNA level in rats. J Nutr Biochem 1994; 5: 291-297.

Sonoyama K, Nishikawa H, Kiriyama S, Niki R. Cholestyramine and a fat-free diet lower apolipoprotein A-IV mRNA in jejunum and cholestyramine lowers apolipoprotein A-I mRNA in ileum of rats. J Nutr 1994; 124: 621-627.


-1993-

Sonoyama K, Kiriyama S, Niki R. Cholestyramine and bile diversion lower the aminopeptidase activity in the intestinal brush border membrane of rats.
J Nutr Sci Vitaminol 1993; 39: 617-625.