遺伝繁殖学研究室
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教授 高橋
mmasashi☆agr.hokudai.ac.jp
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アクセス論文・学会
2023
1. Ho K.T., Balboula A.Z., Homma K., Takanari J., Bai H., Kawahara M.,
Nguyen K.T.K., and Takahashi M. Synergistic effect of standardized extract
of Asparagus officinalis stem and heat shock on progesterone synthesis
with lipid droplets and mitochondrial function in bovine granulosa cells.
The Journal of Steroid Biochemistry and Molecular Biology, 225: 1061812022,
2023.
2. Bai R., Kusama K., Matsuno Y., Bai H., Sakurai T., Kimura K., and Imakawa
K. Expression of NFIL3 and CEBPA regulated by IFNT induced-PGE2 in bovine
endometrial stromal cells during the pre-implantation period. Frontiers
in endocrinology. 14:1075030, 2023.
3. Furukawa E., Yanagawa Y., Matsuzaki A., Kim H., Bai H., Takahashi M.,
Katagiri S., and Higaki S. Analysis of sequential ruminal temperature sensor
data from dairy cows to identify cow subgroups by clustering and predict
calving through supervised machine learning. Journal of Reproduction and
Development. 69: 103-108, 2023.
4. Talukder S.A., Balboula A.Z., Bai H., Kawahara M., Kimura K., and Takahashi
M. IFNT stimulates lysosomal function via type I IFN signaling pathway
in pregnant bovine leukocytes. Reproduction, 166: 411-421, 2023.
5. Komatsu M, Takuma H, Imai S, Yamane M, Takahashi M, Ikegawa T, Bai H,
Ogawa H, and Kawahara M. Dual barrier system against xenomitochondrial
contamination in mouse embryos. Scientific Reports, 13: 23058, 2023
2022
1. Balboula A.Z., Aboelenain M., Sakatani M., Yamanaka K.I., Bai H., Shirozu
T., Kawahara M., Hegab A.E.O., Zaabel S.M., and Takahashi M. Effect of E-64 Supplementation during In Vitro Maturation on the Developmental
Competence of Bovine OPU-Derived Oocytes. Genes, 13: 1-10, doi: 10.3390/genes13020324, 2022.
2. Isoflavones and their metabolites influence the milk production ability
of bovine mammary epithelial cells in a type-specific manner. Tsugami Y., Wakasa H., Kawahara M., Nishimura T., and Kobayashi K. Animal Science Journal, 93: e13720, 2022.
3. Cattle production by intracytoplasmic sperm injection into oocytes vitrified
after ovum pick-up. Kagawa S., Hiraizumi S., Bai H., Takahashi M., and Kawahara M. Theriogenology, 185: 121-126, 2022.
4. Environmental factors affecting the conception rates of nulliparous
and primiparous dairy cattle. Ukita H., Yamazaki T., Yamaguchi S., Abe H., Baba T., Takahashi M., and
Kawahara M., 105: 6947-6955, Journal of Dairy Science, 2022.
5. Generation of viable calves derived from developmentally mature blastocysts
produced by on-gel culture. Saito S., Akizawa H., Furukawa E., Yanagawa Y., Bai H., Takahashi M., and
Kawahara M. Journal of Reproduction and Development, 68: 330-334 2022. Cover Page.
6. Zona pellucida removal by acid Tyrode's solution affects pre- and post-implantation
development and gene expression in mouse embryos. Fan W., Huang T., Wu T., Bai H., Kawahara M., and Takahashi M. Biology of Reproduction, 107: 1228-1241, 2022.
7. Recent progress of interferon-tau research and potential direction beyond
pregnancy recognition. Bai H., Kawahara M., Takahashi M., and Imakawa
K.
Journal of Reproduction and Development, 68: 299-306, 2022. REVIEW
2021
1.Tsugami Y., Wakasa H, Kawahara M., Watanabe A., Suzuki T., Nishimura
T., and Kobayashi K. Adverse effects of LPS on membrane proteins in lactating
bovine mammary epithelial cells. Cell and Tissue Research, 384: 435-448,
2021.
2.Tsugami Y., Wakasa H, Kawahara M., Nishimura T., and Kobayashi K. Lipopolysaccharide
and lipoteichoic acid influence milk production ability via different early
responses in bovine mammary epithelial cells. Experimental Cell Research,
400: 112472, 2021.
3.Saito S., Yamamura S., Kohri N., Bai H., Takahashi M., and Kawahara M.*
Requirement for expression of WW domain containing transcription regulator
1 in bovine trophectoderm development. Biochemical and Biophysical Research
Communications, 555: 140-146, 2021.
4.Kunii H., Kubo T., Asaoka N., Balboula A.Z., Hamaguchi Y., Shimasaki
T., Bai H., Kawahara M., Kobayashi H., Ogawa H., and Takahashi M. Loop-mediated
isothermal amplification (LAMP) and machine learning application for early
pregnancy detection using bovine vaginal mucosal membrane. Biochemical
and Biophysical Research Communications, 569: 179-186, 2021.
5.Murata H., Kunii H., Kusama K., Sakurai T., Bai H., Kawahara M., and
Takahashi T. Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE
pathway in bovine endometrial epithelial cells. Biology of Reproduction,
ioab143, 1-12, 2021.
6.Ho K.T., Homma K., Takanari J., Bai H., Kawahara M., Nguyen K.T.K., and
Takahashi M. A standardized extract of Asparagus officinalis stem improves
HSP70-mediated redox balance and cell functions in bovine cumulus-granulosa
cells. Scientific Reports, 11: 18175, 1-17, 2021.
7.Fan W., Homma M., Xu R., Kunii H., Bai H., Kawahara M., Kawaguchi T.,
and Takahashi M. The use of a two-step removal protocol and optimized culture
conditions improve development and quality of zona free mouse embryos.
Biochemical and Biophysical Research Communications, 577: 116-123, 2021.
8.Hayashi Y., Saito S., Bai H., Takahashi M., and Kawahara M.* Mitochondrial
maturation in the trophectoderm and inner cell mass regions of bovine blastocysts.
Theriogenology, 175: 69-76, 2021.
9.Akizawa H., Saito S., Kohri N., Furukawa E., Hayashi Y., Bai H., Nagano
M., Yanagawa Y., Tsukahara H., Takahashi M., Kagawa S., Kawahara-Miki R.,
Kobayashi H., Kono T., and Kawahara M.* Deciphering two rounds of cell
lineage segregations during bovine preimplantation development. The FASEB
Journal, 10: e21904, 2021.
10.
Komatsu M., Tsukahara H., Bai H., Takahashi M., Wakai T., and Kawahara
M.* Cell-cycle dependent GATA2 subcellular localization in mouse 2-cell
embryos. Biochemical and Biophysical Research Communications, 584: 1-6,
2021.
2020
1.Li J., Maeji M., Balboula A.Z., Aboelenain M., Fujii T., Moriyasu S., Bai
H., Kawahara M., and Takahashi M. Dynamic status of lysosomal cathepsin in bovine oocytes and preimplantation
embryos. Journal of Reproduction and Development, 66: 9-17, 2020.
2.Li J., Balboula A.Z., Aboelenain M., Fujii T., Moriyasu S., Bai H., Kawahara
M., and Takahashi M. Effect of autophagy induction and cathepsin B inhibition on developmental
competence of poor quality bovine oocytes. Journal of Reproduction and Development, 66: 83-91, 2020.
3.Rahman A.M.I., Yamashita S., Islam M.R., Fujihara T., Yamaguchi H., Kawahara
M., Takahashi M., Takahashi H., Gotoh T., and Yamauchi N. Type-I interferon regulates Matrix Metalloproteinases clearance of the
bovine endometrial spheroid. Animal Science Journal, 91: e13350, 2020.
4.Tsugami Y., Suzuki N., Kawahara M., Suzuki T., Nishimura T., and Kobayashi
K. Establishment of an in vitro culture model to study milk production and
the blood-milk barrier with bovine mammary epithelial cells. Animal Science Journal, 91: e13355, 2020.
5.Li G, Li J, Otsuka Y, Zhang S, Takahashi M, Yamada K. A BODIPY-Based Fluorogenic Probe for Specific Imaging of Lipid Droplets. Materials (Basel), 13:677, 2020.
6.Balboula A.Z., Aboelenain M., Li J., Bai H., Kawahara M., Abdel-Ghani
M.A., and Takahashi M. Inverse relationship between autophagy and CTSK is related to bovine embryo
quality. Reproduction, 159: 757-766, 2020.
7.Bai H., Hiura H., Obara Y., Kawahara M., and Takahashi M. Menaquinone-4 (vitamin K2) induces proliferation responses in bovine peripheral
blood mononuclear cells. Journal of Dairy Science, 103: 7531-7534, 2020.
8.Kohri N., Akizawa H., Iisaka S., Bai H., Takahashi T., and Kawahara M. The role of RHOA signaling in trophectoderm cell-fate decision in cattle. Biochemical and Biophysical Research Communications, 528: 713-718, 2020.
9.Balboula A.Z., Schindler K., Kotani T., Kawahara M., and Takahashi M. Vitrification-induced Activation of Lysosomal Cathepsin B Perturbs Spindle
Assembly Checkpoint Function in Mouse Oocytes. Molecular Human Reproduction, 26: 689-701, 2020.
10.Yamamura S., Goda N., Akizawa H., Kohri N., Balboula A.Z., Kobayashi
K., Bai H., Takahashi M., and Kawahara M. Yes-associated protein 1 translocation through actin cytoskeleton organization
in trophectoderm cells. Developmental Biology, 468: 14-25, 2020.
プレスリリース: https://www.hokudai.ac.jp/news/pdf/200930_pr2.pdf
11.Bai H., Ukita H., Kawahara M., Mitani T, Furukawa E., Yanagawa Y., Yabuuchi
N, Kim H, Takahashi M. Effect of summer heat stress on gene expression in bovine uterine endometrial
tissues. Animal Science Journal, 2020, IN PRESS.
2019
1.Akizawa H., Yanagawa Y., Nagano M., Bai H., Takahashi M. and Kawahara M. Significance of CCN2 expression in bovine preimplantation development. Animal Science Journal, 90: 49-54, 2019.
2.Shiina K., Komatsu M., Yokoi F., Bai H., Takahashi M. and Kawahara M. Overgrowth of mice generated from postovulatory aged oocyte spindles. FASEB
BioAdvances, 1: 393-403, 2019.
3.Bai H., Talukder M.A.S., Kunii H., Itoh T., Kawahara M. and Takahashi
M. Evaluation of the immune status of peripheral blood monocytes from dairy
cows during the periparturition period. Journal of Reproduction and Development, 65: 313-318, 2019.
4.Oikawa K., Yamazaki T., Yamaguchi S., Abe H., Bai H., Takahashi M., and
Kawahara M. Effects of use of conventional and sexed semen on the conception rate in
heifers: a comparison study. Theriogenology, 135: 33-37, 2019.
5.Kohri N., Akizawa H., Iisaka S., Bai H., Yanagawa Y., Takahashi M., Komatsu
M., Kawai M., Nagano M., and Kawahara M. Trophectoderm regeneration to support full-term development in the inner
cell mass isolated from bovine blastocyst. Journal of Biological Chemistry, 294: 19209-19223, 2019.
2018
1. Yamanaka KI, Khatun H, Egashira J, Balboula AZ, Tatemoto H, Sakatani
M, Takenouchi N, Wada Y, Takahashi M. Heat-shock-induced cathepsin B activity
during IVF and culture compromises the developmental competence of bovine
embryos. Theriogenology, 114: 293-300, 2018.
2. Talukder MAS, Balboula AZ, Shirozu T, Kim SW, Kunii H, Suzuki T, Ito
T, Kimura K, Takahashi M. Activation of lysosomal cathepsins in pregnant
bovine leukocytes. Reproduction, 155: 515-528, 2018.
3. Kikuchi K., Sasaki K., Akizawa H., Tsukahara H., Bai H., Takahashi M., Nambo Y., Hata H. and Kawahara M. Identification and expression analysis of cDNA encoding insulin like growth
factor 2 in horse. Journal of Reproduction and Development, 64: 57-64, 2018.
4. Kikuchi K., Kozai K., Hojo T., Sakatani M., Okuda K., Bai H., Kawahara
M., and Takahashi M. Evaluating the electrical impedance and mucus-related gene expression of
uterine endometrial tissues in mares. Journal of Reproduction and Development, 64: 193-197, 2018.
5. Akizawa H., Kobayashi K., Bai H., Takahashi M., Kagawa S., Nagatomo
H. and Kawahara M. Reciprocal regulation of TEAD4 and CCN2 for the trophectoderm development
of the bovine blastocyst. Reproduction, 155: 563-571, 2018.
6. Nakahara K., Sakuma S., Kawahara M., Takahashi M., and Arai F. Time-lapse mechanical characterization of zona pellucida using a cell carrier
chip. Journal of Microelectromechanical Systems, 27: 464-471, 2018.
7. Kunii H., Koyama K., Ito T., Suzuki T., Balboula A.Z., Shirozu T., Bai
H., Nagano M., Kawahara M., and Takahashi M. Pregnancy-induced expression of interferon-stimulated genes in cervical
and vaginal mucosal membrane. Journal of Dairy Science,101: 8396-8400, 2018.
8. Musavi S.A.A., Yamashita S., Fujihara T., Masaka H., Islam M.R., Kim
S., Goto T., Kawahara M., Tashiro K., and Yamauchi N. Analysis of differentially expressed genes and the promoters in bovine
endometrium throughout estrus cycle and early pregnancy. Animal Science Journal, 89: 1609-1621, 2018.
9. Suzuki T., Sakumoto R., Hayashi K.G., Ogiso T., Kunii H., Shirozu T.,
Kim S.W., Bai H., Kawahara M., Kimura K., and Takahashi M. Involvement of IFNT in the induction of apoptotic, pyroptotic and autophagic
cell death-related signaling pathways in bovine uterine endometrium during
early pregnancy. Journal of Reproduction and Development, 64: 495-502, 2018.
2017
1.Balboula AZ, Blengini CS, Gentilello AS, Takahashi M, Schindler K, Maternal
RNA regulates Aurora C kinase during mouse oocyte maturation in a translation-independent
fashion. Biol Reprod. 96: 1197-1209. 2017
2.Shirozu T., Iwano H., Ogiso T., Suzuki T., Balboula AZ., Bai H., Kawahara M., Kimura K., Takahashi H., Bai R., Kim SW., Yanagawa
Y., Nagano M., Imakawa K., Takahashi M. Estrous cycle stage-dependent manner of type I interferon-stimulated genes
1 induction in the bovine endometrium. Journal of Reproduction and Development.
63: 211-220, 2017.
3.Aboelenain M., Balboula AZ., Kawahara M., Montasser Ael-M., Zaabel SM.,
Kim SW., Nagano M., Takahashi M．
4.Sakatani M., Yamanaka K., Balboula AZ., Takahashi M., Different thermotolerance in in-vitro-produced embryos derived from different
maternal and paternal genetic backgrounds. Anim Sci J. doi: 10.1111/asj.12875.2017.
5.Kaneda M., Takahashi M., Yamanaka K., Saito K., Taniguchi M., Akagi S.,
Watanabe S., Nagai T. Epigenetic analysis of bovine parthenogenetic embryonic
fibroblast cells. Journal of Reproduction and Development. 63:365-375,
2017.
6.Yan W., Kanno C., Oshima E., Kuzuma Y., Kim S.W., Bai H., Takahashi M.,
Yanagawa Y., Nagano M., Wakamatsu J.I., and Kwahara M.Enchancement of sperm
motility and viability by turmeric by-product dietary suplimentation in
roosters. Animal Reproduction Science, 185: 195-204, 2017.
2016
1.Shirozu T., Sasaki K., Kawahara M., Yanagawa Y., Nagano M., Yamauchi
N., and Takahashi M. Expression dynamics of bovine MX gene in the endometrium
and placenta during early to mid-pregnancy. Journal of Reproduction and
Development, 62: 29-35, 2016.
2.Sasaki K., Tanaka A, Nagatomo H., Ogawa H., Kobayashi K., Takahashi M.,
and Kawahara M. Characterization of Toll-Like Receptor 9 expression during
mouse preimplantation development. Journal of Genital System & Disorders,
5: 1-5, 2016.
3.Nagatomo H., Kohri N., Akizawa H., Hoshino Y., Yamauchi N., Kono T.,
Takahashi M., and Kawahara M. Requirement for nuclear autoantigenic sperm
protein mRNA expression in bovine preimplantation development. Animal Science
Journal, 87: 457-461, 2016.
4.Akizawa H., Nagatomo H., Odagiri H., Kohri N., Yamauchi N., Yanagawa
Y., Nagano M., Takahashi M., and Kawahara M. Conserved roles of fibroblast
growth factor receptor 2 signaling in the regulation of inner cell mass
development in bovine blastocysts. Molecular Reproduction and Development,
83: 516-25, 2016.
5.Sakatani M., Takahashi M., Takenouchi N., The efficiency of vaginal temperature
measurement to detect the estrus in Japanese Black cows. J Reprod Dev.62:
201-207, 2016.
6.Kozai K., Tokuyama S., Szóstek A.Z., Toishi Y., Tsunoda N., Taya K.,
Sakatani M., Takahashi M., Nambo Y., Skarzynski D., Yamamoto Y., Kimura
K., and Okuda K. Evidence for a PGF2α auto-amplification system in the
endometrium in the mare. Reproduction, 151: 517-526, 2016.
7.Yamazaki W., Amano T., Bai H., Takahashi M., and Kawahara M. The Influence
of Polyploidy and Genome Composition on Genomic Imprinting in Mice. The
Journal of Biological Chemistry, 291: 20924-20931,, 2016.
2015
1.Sakatani M, Yamanaka K, Balboula AZ, Takenouchi N, Takahashi M. Heat
stress during in vitro fertilization decreases fertilization success by
disrupting anti-polyspermy systems of the oocytes. Molecular Reproduction
and Development, 82 :36-47, 2015.
2.Aboelenain M., Kawahara M., Balboula A.Z., Montasser A.E., Zaabel S.M.,
Okuda K., and Takahashi M. Status of autophagy, lysosome activity and apoptosis
during corpus luteum regression in cattle. Journal of Reproduction and
Development, 61: 229-236, 2015.
3.Nagatomo H., Akizawa H., Sada A., Kishi Y., Yamanaka K.I., Takuma T.,
Sasaki K., Yamauchi N., Yanagawa Y., Nagano M., Kono T., Takahashi M.,
and Kawahara M. Comparing spatial expression dynamics of bovine blastocyst
under three different procedures: in-vivo, in-vitro, and somatic cell nuclear
transfer embryos. The Japanese Journal of Veterinary Research, 63: 159-171,
2015..
4.Kawahara M., Koyama S., Iimura S., Yamazaki W., Tanaka A., Kohri N.,
Sasaki K., and Takahashi M. Preimplantation death of xenomitochondrial
mouse embryo harbouring bovine mitochondria.
Scientific Reports, 5:14512.doi:10.1038/srep14512., 2015.
.
解説 夏季の暑熱と人工受精受胎率. 高橋昌志．LIAJ news, 153:6-8.
総説 夏季の暑熱ストレスによる繁殖性への影響．高橋昌志．臨床獣医、5月号.12-17．
2014
1. Bai H, Sakurai T, Godkin JD, Imakawa K. Expression and in situ localization
of GATA4, 5 and 6 mRNAs in ovine conceptuses and uterine endometria during
the peri-implantation period. Animal Sciences Journal, 85: 388-394, 2014.
2. Bai H, Sakurai T, Bai R, Yamakoshi S, Aoki E, Kuse M, Okuda K, Imakawa
K. Establishment and characterization of immortalized bovine endometrial
epithelial cells. Animal Sciences Journal, 85: 799-804, 2014.
3. Bai R, Bai H, Kuse M, Ideta A, Aoyagi Y, Fujiwara H, Okuda K, Imakawa
K, akurai T. Involvement of VCAM-1 in the bovine conceptus adhesion to
the uterine endometrium. Reproduction,148:119-127, 2014.
4. Tachibana Y, Sakurai T, Bai H, Shiota K, Nambo Y, Nagaoka K, Imakawa
K. RNA-seq analysis of equine conceptus transcripts during embryo fixation
and capsule disappearance. PLoS One, 9: e114414, 2014.
5.Yamazaki W, Takahashi M, Kawahara M. Restricted development of mouse
triploid fetuses with disorganized expression of imprinted genes. Zygote,
[Epub ahead of print], 2014
6.Yamagami K, Yamauchi N, Kubota K, Nishimura S, Chowdhury VS, Yamanaka
K, Takahashi M, Tabata S, and Hattori MA. Expression and regulation of
Foxa2 in the rat uterus during early pregnancy. J Reprod Dev, 60:468-475,
2014.
7.Kozai K, Hojo T, Tokuyama S, Szóstek AZ, Takahashi M, Sakatani M, Nambo
Y, Skarzynski DJ, and Okuda K. Expression of aldo-keto reductase 1C23 in
the equine corpus luteum in different luteal phases. J Reprod Dev, 60 :150-154,
2014.
8.Takahashi H, Tsunazaki M, Hamano T, Takahashi M, Okuda K, Inumaru S,
Okano A, Geshi M, Hirako M. Biological activity of recombinant bovine interferon
τ produced by a silkworm-baculovirus gene expression system. J Vet Med
Sci, 76 :4474-4451, 2014.
2013
1.Nakagawa S, Bai H, Sakurai T, Nakaya Y, Konno T, Miyazawa T, Gojobori
T, Imakawa K. Dynamic evolution of endogenous retrovirus-derived genes
expressed in bovine conceptuses during the period of placentation. Genome
Biology and Evolution, 5: 296-306, 2013.
2.Sakurai T, Bai H, Bai R, Sato D, Arai M, Okuda K, Ideta A, Aoyagi Y,
Godkin JD, Imakawa K. Down-regulation of interferon tau gene transcription
with a transcription factor, EOMES. Molecular Reproduction and Development,
80: 371-383, 2013.
3.Kim MS, Sakurai T, Bai H, Bai R, Sato D, Nagaoka K, Chang KT, Godkin
JD, Min KS, Imakawa K. Presence of transcription factor OCT4 limits interferon-tau
expression during the pre-attachment period in sheep. Asian-Australasian
Journal of Animal Sciences, 26: 638-645, 2013.
4.Sakurai T, Nakagawa S, Kim MS, Bai H, Bai R, Li J, Min KS, Ideta A, Aoyagi
Y, Imakawa K. Transcriptional regulation of two conceptus interferon tau
genes expressed in japanese black cattle during peri-implantation period.
PLoS One, 8: e80427, 2013.
5.Aono A., Nagatomo H., Takuma T., Nonaka R., Ono Y., Wada Y., Abe Y.,
Takahashi M., Watanabe T. and Kawahara M. Dynamics of intracellular phospholipid
membrane organization during oocyte maturation and successful vitrification
of immature oocytes retrieved by ovum pick-up in cattle. Theriogenology,
79: 1146-1152, 2013.
6.Sasaki K., Yoneda A., Ninomiya A., Kawahara M. and Watanabe T. Both antiviral
activity and intracellular localization of chicken Mx protein depend on
a polymorphism at amino acid position 631. Biochemical and Biophysical
Research Communications, 430: 161-166, 2013.
7.Nagatomo H., Kagawa S., Kishi Y., Takuma T., Sada A., Yamanaka KI., Abe
Y., Wada Y., Takahashi M., Kono T. and Kawahara M. Transcriptional wiring
for establishing cell lineage specification at the blastocyst stage in
cattle. Biology of Reproduction, DOI 10.1095/biolreprod.113.108993, 2013.
8.Sugawara S, Ito T, Sato T, Yokoo M, Mori Y. Kasuga K, Kojima I, Fukuda
T, Yamanaka K, Sakatani M, Takahashi M, Kobayashi M. Production of bioactive
bovine fibroblast growth factor 4 in E. coli based on the common nucleotide
sequence of its structural gene in three breeds. Animal Science Journal.
84:275-280. 2013.
9.Balboula AZ, Yamanaka K, Sakatani M, Kawahara M,Hegab AO, Zaabel SM,
Takahashi M, Cathepsin B activity has a crucial role in the developmental
competence of bovine cumulus?oocyte complexes exposed to heat shock during
in vitro maturation. Reproduction. 146:407-417, 2013.
10.Sasaki K., Kawahara M. and Watanabe T. Characteristics of mx gene that
shows resistance to vesicular stomatitis virus from avians to mammals.
Advances in Genetics Research, NOVA Science publishers, New York, USA,
Chapter 6, 11:p117-130, 2013.
11.Sasaki K., Tungtrakoolsub P., Morozumi T., Uenishi H., Kawahara M. and
Watanabe T. A single nucleotide polymorphism of porcine MX2 gene provides
antiviral activity against vesicular stomatitis virus. Immunogenetics,
66 :25-32, 2014.
家畜の繁殖研究の流れと展望、高橋昌志、日本胚移植学雑誌、35巻１－８．
2012
1.Takahashi M, A review: Effect of intracellular redox status and its regulation
on bovine embryonic development. Journal of Reproduction and Development.58:1-9.2012.
2.Sakatani M, Alvarez NV, Takahashi M, Hansen PJ. Consequences of physiological
heat shock beginning at the zygote stage on embryonic development and expression
of stress response genes in cattle. Journal of Dairy Science. 95:3080-91.
2012.
3.Matsunari H, Maehara M, Nakano K, Ikezawa Y, Hagiwara Y, Sasayama N,
Shirasu A, Ohta H, Takahashi M, Nagashima H. Hollow fiber vitrification:
a novel method for vitrifying multiple embryos in a single device. Journal
of Reproduction and Development. 58:599-608, 2012.
4.Maehara M, Matsunari H, Honda K, Nakano K, Takeuchi Y, Kanai T, Matsuda
T, Matsumura Y, Hagiwara Y, Sasayama N, Shirasu A, Takahashi M, Watanabe
M, Umeyama K, Hanazono Y, Nagashima H. Hollow fiber vitrification provides
a novel method for cryopreserving in vitro maturation/fertilization-derived
porcine embryos. Biology of Reproduction. 87:133. doi: 10.1095/biolreprod.112.100339.2012.
5.Kozai K, Hojo T, Takahashi M, Acosta TJ, Nambo Y, Okuda K. Seasonal Changes
in Luteal Progesterone Concentration and mRNA Expressions of Progesterone
Synthesis-Related Proteins in the Corpus Luteum of Mares. Journal of Reproduction
and Development. 58:393-397, 2012.
6.Kawahara M. and Kono T. Roles of genes regulated by two paternally methylated
imprinted regions on chromosomes 7 and 12 in mouse ontogeny. Journal of
Reproduction and Development, 58: 175-179, 2012.
2011
1.Yamanaka K, Kaneda M, Inaba, Y, Saito K, Bubota K, Sakatani M, Sugimura
S, Imai, K,Watanabe S, Takahashi M. DNA methylation analysis on satellite
I region in blastocysts obtained from somatic cell cloned cattle. Animal
Science Journal , 82:523-530.2011.
2.Yamanaka K, Sakatani M, Kubota K, Balboula AZ, Sawai K, Takahashi M, Effects
of downregulating DNA methyltransferase 1 transcript by RNA interference
on DNA methylation status on satellite I region and in vitro development
of bovine somatic cell nuclear transfer embryos. Journal of Reproduction
and Development. 57: 393-402.2011.
3.Nakano K, Matsunari H, Nakayama N, Ogawa B, Kurome M, Takahashi M, Matsumoto
M, Murakami H, Kaji Y, Nagashima H, Cloned porcine embryos can maintain
developmental ability after cryopreservation at the morula stage. Journal
of Reproduction and Development. 57:312-316.2011.
4.Sawai K, Takahashi M, Fujii T, Moriyasu S, Hirayama H, Minamihashi A,
Hashizume T, Onoe S. DNA methylation status of bovine blastocyst obtained
from various procedures. Journal of Reproduction and Development, 57:236-241.2011.
5.Sakatani M, Balboula AZ, Yamanaka K, Takahashi M, Effect of summer heat
environment on body temperature, estrous cycles and blood antioxidant levels
in Japanese Black cow, Animal Science Journal, 82:523-530.2011.
6.Takahashi M, A review: Heat stress on reproductive function and fertility
in mammals, Reproducive Medicine and Biology. DOI10. 1007/s12522-011-0105-6.
2011.
2010
1.Sawai K, Takahashi M, Moriyasu S, Hirayama H, Minamihashi A, Hashizume
T, Sadao Onoe S, Changes in the DNA methylation status of bovine embryos
from the blastocyst to elongated stage derived from somatic cell nuclear
transfer. Cloning and Stem cells. 12:15-22. 2010.
2.Yamanaka K, Balboula AZ, Sakatani M, Takahashi M, Gene Silencing of DNA
Methyltransferases by RNA Interference in Bovine Fibroblast Cells. Journal
of Reproduction and Development. 56:60-67. 2010.
3.Balboula AZ, Yamanaka K, Sakatani M, Hegab AO, Zaabel SM, Takahashi M.
Cathepsin B activity is related to the quality of bovine cumulus oocyte
complexes and its inhibition can improve their developmental competence.
Molecular Reproduction and Development. 77:439-448. 2010.
4.Tani M, Hayashida T, Tomokawa K, Mito Y, Funakoshi D, Tani C, Sakatani
M, Takahashi M, Kitahara G, Kamimura S. Effect of embryo transfer following
artificial insemination (ETFAI) on reproductive performance in dairy cows
in South-Western Japan. Journal of Veterinary Medical Science. 72:627-629.
2010.
5.Kubota K, Yamauchi N, Yamagami K, Nishimura S, Gobaru T, Yamanaka K,
Wood C, Soh T, Takahashi M, Hattori MA, Steroidal regulation of Ihh and
Gli1 expression in the rat uterus, Cell and Tissue Research. 40:389-395.
2010.
6.Balboula AZ, Yamanaka K, Sakatani M, Hegab AO, Zaabel SM, Takahashi M.
Compromising role of intracellular cathepsin B on the quality and developmental
competence of bovine preimplantation embryos, Molecular Reproduction and
Development.77:1031-1039. 2010.
7.Siemieniuch MJ, Majewska M, Takahashi M, Sakatani M, ?ukasik K, Okuda
K, Skarzynski DJ, Are glucocorticoids auto- and/or paracrine factors in
early bovine embryo development and implantation? Reproductive Biology
10:249-256. 2010.
8.Kawahara M., Wu Q. and Kono T. Involvement of insulin-like growth factor
2 in angiogenic factor transcription in bi-maternal mouse conceptuses.
Journal of Reproduction and Development, 56: 79-85, 2010.
9.Sugimura S., Yamanaka K., Kawahara M., Wakai T., Yokoo M. and Sato E.
Early metaphase II oocytes treated with dibutyryl cyclic adenosine monophosphate
provide suitable recipient cytoplasm for the production of miniature pig
somatic cell nuclear transfer embryos. Animal Science Journal, 81: 48-57,
2010.
10.Kawahara M. and Kono T. Longevity in mice without a father. Human Reproduction,
25: 457-461, 2010.
11.Sugimura S., Yokoo M., Yamanaka KI., Kawahara M., Moriyasu S., Wakai
T., Nagai T., Abe H. and Sato E. Anomalous oxygen consumption in porcine
somatic cell nuclear transfer embryos. Cellular Reprogramming, 12: 463-474,
2010.
2009
1.Sakurai T, Sakamoto A, Muroi Y, Bai H, Nagaoka K, Tamura K, Takahashi
T, Hashizume K, Sakatani M, Takahashi M, Godkin JD, Imakawa K. Induction
of Endogenous Tau Interferon Gene Transcription by CDX2 and High Acetylation
in Bovine Non-Trophoblast Cells. Biology of Reproduction. 80:1223-1231,
2009.
2.Bai H, Sakurai T,Kim MS, Muroi Y,Ideta A, Aoyagi Y, Nakajima H, Takahashi
M, Nagaoka K, Imakawa K, InvolvementQ1 of GATA Transcription Factors in
the Regulation of Endogenous Bovine Interferon-Tau Gene Transcription,
Molecular Reproduction and Development, 76:1143-1152, 2009.
3.Ogawa H., Shindo N., Kumagai T., Usami Y., Shikanai M., Jonwn K., Fukuda
A., Kawahara M., Sotomaru Y., Tanaka S., Arima T. and Kono T. Developmental
Ability of Trophoblast Stem Cells in Uniparental Mouse Embryos. Placenta,
30: 448-456, 2009.
4.Kawahara M., Morita S., Takahashi N. and Kono T. Defining contributions
of paternally methylated imprinted genes at the IGF2-H19 and DLK1-GTl2
domains to mouse placentation by transcriptomic analysis. The Journal of
Biological Chemistry, 284: 17751-17765, 2009.
5.Yamanaka K.I., Sugimura S., Wakai T., Kawahara M. and Sato E. Acetylation
level of histone H3 in early embryonic stages affects subsequent development
of miniature pig somatic cell nuclear transfer embryos. Journal of Reproduction
and Development, 55: 638-644, 2009.
βメルカプトエタノールが毒劇物指定を受けての家畜生殖細胞操作・培養への対応. 高橋昌志．日本胚移植学雑誌31:127-133．
体細胞クローン作出におけるエピジェネティックス研究の現状．山中賢一、高橋昌志、日本胚移植学雑誌30:99-105．
2008
1.Sakatani M, Yamanaka K, Kobayashi S, Takahashi M,. Heat shock-derived
reactive oxygen species induce embryonic mortality in in vitro early stage
bovine embryos. Journal of Reproduction and Development, 54,486-501, 2008.
2.Wakai T., Tanaka H., Yamanaka K.I., Sugimura S., Sasada H., Kawahara
M., Kobayashi E., and Sato E. Induction of estrus in pubertal miniature
gilts. Animal Reproduction Science, 103: 193-198, 2008.
3.Sugimura S., Kawahara M., Wakai T., Yamanaka K.I., Sasada H., and Sato
E. Effect of cytochalasins B and D on the developmental competence of somatic
cell nuclear transfer embryos in miniature pigs. Zygote, 16: 153-159, 2008.
*These authors contributed equaly to this work.
4.Kawahara M., Obata Y., Sotomaru Y., Shimozawa N., Bao S., Tsukadaira
T., Fukuda A. and Kono T. Protocol for the production of viable bi-maternal
mouse embryos. Nature Protocols, 3: 197-209, 2008.
5.Jincho Y., Sotomaru Y., Kawahara M., Ogawa H., Obata Y., and Kono T.
Identification of Genes Aberrantly Expressed in Mouse Embryonic Stem Cell-Cloned
Blastocysts. Biology of Reproduction, 78: 568-576, 2008.
6.Wakai T., Sugimura S., Yamanaka K.I., Kawahara M., Sasada H., Tanaka
H., Ando A., Kobayashi E., and Sato E. Production of viable cloned miniature
pig embryos using oocytes derived from domestic pig ovaries. Cloning and
Stem Cells, 10: 249-262, 2008.
7.Wu Q., Kawahara M. and Kono T. Synergistic role of Igf2 and Dlk1 in fetal
liver development and hematopoiesis in bi-maternal mice. Journal of Reproduction
and Development, 54: 177-182, 2008.
2007
1.Sakatani M, Suda I, Oki T, Kobayashi S, Kobayashi S, Takahashi M, Effects
of purple sweet potato anthocyanins on development and intracellular redox
status of bovine preimplantation embryos exposed to heat shock. Journal
of Reproduction and Development. 53:605-614, 2007.
2.Suzuki C, Yoshioka K, Sakatan M, Takahashi M, Glutamine and Hypotaurine
Improves Intracellular Oxidative Status and In Vitro Development of Porcine
Preimplantation Embryos. Zygotes. 15:317-324. 2007.
3.Kobayashi S, Sakatani M, Kobayashi S, Okuda K, Takahashi M, Gene Silencing
of Cyclooxygenase-2 mRNA by RNA Interference in Bovine Cumulus-Granulosa
cells. Journal of Reproduction and Development. 53: 1305-1311, 2007.
4.Matsumoto S, Okumura K, Ogata A, Hisatomi Y, Sato A, Hattori K, Matsumoto
M, Kaji Y, Takahashi M, Yamamoto T, Nakamura K, Endo F, Isolation of tissue
progenitor cells from duct-ligated salivary glands of swine. Cloning and
Stem Cells. 9:176-190, 2007.
5.Kawahara M., Wu Q., Takahashi N., Morita S., Yamada K., Ito M., Ferguson-Smith
A.C., and Kono T. High-frequency generation of viable mice from engineered
bi-maternal embryos. Nature Biotechnology, 25: 1045-1050, 2007.
6.Kawahara M., Wu Q., Ferguson-Smith A.C., and Kono T. Appropriate expression
of paternally methylated imprinted genes on chromosome 12 leads to extended
development of bi-maternal embryos to term but lethal. FEBS letters, 581:
5178-5184, 2007.
7.Wakai T., Kawahara M., Yamanaka K.I., Hoshino Y., Tomioka I, Sugimura
S., Sugawara A., and Sato E. Morphological aspects of porcine embryos reconstructed
by somatic cell nuclear transfer. Morphology, 2, 23-24, 2007.